Phospho-Slingshot homolog 1 Positive Control | SSH1 positive control
Phospho Slingshot homolog 1 Antibody Western Blot Positive Control
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Uniprot Description
SSH1: a dual-specificity phosphatase of the Slingshot family involved in actin reorganization. Its calcineurin-dependent activation dephosphorylates cofilin. Plays a role in later stages of mitosis by dephosphorylating and activating cofilin.
Protein type: EC 3.1.3.48; Protein phosphatase, dual-specificity; EC 3.1.3.16
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: cleavage furrow; cytoplasm; cytoskeleton; lamellipodium; midbody; nucleoplasm; plasma membrane
Molecular Function: actin binding; DNA binding; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
Biological Process: actin cytoskeleton organization and biogenesis; cell morphogenesis; protein amino acid dephosphorylation; regulation of actin polymerization and/or depolymerization; regulation of axonogenesis; regulation of cellular protein metabolic process
Research Articles on SSH1
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Product Notes
The SSH1 ssh1 (Catalog #AAA543171) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Phospho-Slingshot homolog 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500. Researchers should empirically determine the suitability of the SSH1 ssh1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Phospho-Slingshot homolog 1, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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