Western Blot (WB)
PBR positive control
PBR Positive Control
Western Blot (WB)
Western Blot (WB)
Can bind protoporphyrin IX and may play a role in transport of porphyrins and heme. Promotes transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism.
NCBI and Uniprot Product Information
NCBI Description
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]
Uniprot Description
TSPO: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells. Belongs to the TspO/BZRP family. Interacts with BZRAP1. May interact with STAR. Interacts with MOST-1. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.; Membrane protein, multi-pass; Apoptosis; Mitochondrial
Chromosomal Location of Human Ortholog: 22q13.31
Cellular Component: cytoplasm; integral to membrane; intracellular membrane-bound organelle; mitochondrial outer membrane; mitochondrion; nuclear membrane
Molecular Function: androgen binding; benzodiazepine receptor activity; cholesterol binding; protein binding
Biological Process: adrenal gland development; aging; anion transport; apoptosis; axon regeneration in the peripheral nervous system; behavioral response to pain; cell proliferation; chloride transport; glial cell migration; heme biosynthetic process; lipid transport; negative regulation of nitric oxide biosynthetic process; negative regulation of protein ubiquitination; negative regulation of tumor necrosis factor production; positive regulation of apoptosis; positive regulation of calcium ion transport; positive regulation of mitochondrial depolarization; protein targeting to mitochondrion; regulation of cholesterol transport; regulation of steroid biosynthetic process; response to drug; response to manganese ion; response to progesterone stimulus; response to testosterone stimulus; response to vitamin B1; steroid biosynthetic process; steroid metabolic process
Research Articles on PBR
Similar Products
Product Notes
The PBR tspo (Catalog #AAA543359) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's PBR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500. Researchers should empirically determine the suitability of the PBR tspo for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PBR, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
