Nicotinic Acetylcholine Receptor alpha 7 Positive Control | Chrna7 positive control
Nicotinic Acetylcholine Receptor alpha 7 Positive Control
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
NCBI and Uniprot Product Information
NCBI Description
subunit of nicotinic acetylcholline receptor; may mediate nicotine induced increase in tyrosine hydroxylase expression; may play a role in neuroprotection [RGD, Feb 2006]
Uniprot Description
nAChRA7: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 7/CHRNA7 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Channel, cation; Membrane protein, integral
Cellular Component: apical plasma membrane; asymmetric synapse; axolemma; axon; cell junction; cell soma; cytoplasm; dendrite; dendritic shaft; dendritic spine; external side of plasma membrane; growth cone; integral to membrane; lipid raft; membrane; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic membrane
Molecular Function: acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated cation channel activity; adenylate cyclase binding; ATPase binding; beta-amyloid binding; chloride channel regulator activity; drug binding; nicotinic acetylcholine-activated cation-selective channel activity; protein binding; protein homodimerization activity; protein kinase binding; toxin binding
Biological Process: activation of MAPK activity; associative learning; B cell activation; behavioral response to ethanol; behavioral response to nicotine; calcium ion transport; cellular calcium ion homeostasis; cognition; dopamine biosynthetic process; endocytosis; generation of action potential; generation of ovulation cycle rhythm; ion transport; memory; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production; ovulation cycle; positive regulation of angiogenesis; positive regulation of cell proliferation; positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressure; regulation of inflammatory response; regulation of membrane potential; regulation of norepinephrine secretion; regulation of synaptic transmission, dopaminergic; response to ethanol; response to food; response to hypoxia; response to nicotine; signal transduction; sperm motility; synaptic transmission, cholinergic; T cell activation
Research Articles on Chrna7
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Product Notes
The Chrna7 chrna7 (Catalog #AAA542977) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Nicotinic Acetylcholine Receptor alpha 7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:250. Researchers should empirically determine the suitability of the Chrna7 chrna7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Nicotinic Acetylcholine Receptor alpha 7, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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