Porcine Mediator of RNA polymerase II transcription subunit 14 (MED14) ELISA Kit | MED14 elisa kit

Porcine Mediator of RNA polymerase II transcription subunit 14 (MED14) ELISA Kit

Cat. Num. AAA7221357

• Gene Names: MED14; CSRP; RGR1; CRSP2; EXLM1; CXorf4; CRSP150; DRIP150; TRAP170
• Reactivity: Porcine
• Synonyms: Mediator of RNA polymerase II transcription subunit 14 (MED14); Porcine Mediator of RNA polymerase II transcription subunit 14 (MED14) ELISA Kit; MED14 elisa kit

• Reactivity: Porcine

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for MED14 elisa kit

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 28558973
• NCBI GeneID: 9282
• NCBI Accession #: NP_004220.2
• NCBI GenBank Nucleotide #: NM_004229.3
• Molecular Weight: 160,607 Da
• NCBI Official Full Name: mediator of RNA polymerase II transcription subunit 14
• NCBI Official Synonym Full Names: mediator complex subunit 14
• NCBI Official Symbol: MED14
• NCBI Official Synonym Symbols: CSRP; RGR1; CRSP2; EXLM1; CXorf4; CRSP150; DRIP150; TRAP170
• NCBI Protein Information: mediator of RNA polymerase II transcription subunit 14; hRGR1; ARC150; RGR1 homolog; CRSP complex subunit 2; human homolog of yeast RGR1; transcriptional co-activator CRSP150; activator-recruited cofactor 150 kDa component; vitamin D receptor-interacting protein complex component DRIP150; vitamin D3 receptor-interacting protein complex 150 kDa component; thyroid hormone receptor-associated protein complex 170 kDa component; thyroid hormone receptor-associated protein complex component TRAP170; cofactor required for Sp1 transcriptional activation, subunit 2 (150kD)
• UniProt Protein Name: Mediator of RNA polymerase II transcription subunit 14
• Protein Family: Mediator of RNA polymerase II transcription
• UniProt Gene Name: MED14
• UniProt Synonym Gene Names: ARC150; CRSP2; CXorf4; DRIP150; EXLM1; RGR1; TRAP170; ARC150; CRSP complex subunit 2; hRGR1; Trap170; DRIP150
• UniProt Entry Name: MED14_HUMAN

NCBI Description

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]

Uniprot Description

Trap170: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 14 family.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: Xp11.4

Cellular Component: nucleoplasm; membrane; Srb-mediator complex; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor transcription coactivator activity; vitamin D receptor binding; transcription coactivator activity; transcription cofactor activity; thyroid hormone receptor binding; receptor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; stem cell maintenance; androgen receptor signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter