Porcine CAP-Gly domain-containing linker protein 1 (CLIP1) ELISA Kit | CLIP1 elisa kit
Porcine CAP-Gly domain-containing linker protein 1 (CLIP1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Description
Restin: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Interacts with MTOR; phosphorylates and regulates CLIP1. Interacts (via CAP-Gly domains) with tubulin. Interacts with SLAIN2. Interacts (via zinc finger) with DCTN1. Interacts with MAPRE1 and MAPRE3. Detected in dendritic cells. Highly expressed in the Reed-Sternberg cells of Hodgkin disease. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q24.3
Cellular Component: kinetochore; microtubule cytoskeleton; ruffle; centrosome; microtubule; cytoplasmic vesicle membrane; cytoplasmic microtubule; cytoplasm; intermediate filament; cytosol; endosome
Molecular Function: tubulin binding; microtubule plus-end binding; protein binding; protein homodimerization activity; nucleic acid binding; zinc ion binding; microtubule binding; metal ion binding
Biological Process: mitosis; positive regulation of microtubule polymerization; mitotic cell cycle; microtubule bundle formation