Porcine Calcipressin-1 (RCAN1) ELISA Kit | RCAN1 elisa kit
Porcine Calcipressin-1 (RCAN1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Uniprot Description
RCAN1: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Interacts with RAF1. By calcium. Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. Belongs to the RCAN family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 21q22.12
Cellular Component: nucleus
Molecular Function: identical protein binding; protein binding; DNA binding; transcription factor activity
Biological Process: central nervous system development; regulation of transcription, DNA-dependent; blood circulation; calcium-mediated signaling; signal transduction
Research Articles on RCAN1
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Product Notes
The Porcine RCAN1 rcan1 (Catalog #AAA7226046) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7226046 ELISA Kit recognizes Porcine RCAN1. It is sometimes possible for the material contained within the vial of "Calcipressin-1 (RCAN1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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