Rabbit anti-Human ZNRF3 Polyclonal Antibody | anti-ZNRF3 antibody
ZNRF3 Antibody; HRP conjugated
NCBI and Uniprot Product Information
Uniprot Description
ZNRF3: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Belongs to the ZNRF3 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.19; Ubiquitin ligase; EC 6.3.2.-; Membrane protein, integral; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 22q12.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: frizzled binding; ligase activity; protein binding; ubiquitin-protein ligase activity; zinc ion binding
Biological Process: protein ubiquitination; ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, planar cell polarity pathway
Research Articles on ZNRF3
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Product Notes
The ZNRF3 znrf3 (Catalog #AAA7002169) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ZNRF3 Antibody; HRP conjugated reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ZNRF3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the ZNRF3 znrf3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZNRF3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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