Rabbit anti-Human ZNF521 Polyclonal Antibody | anti-ZNF521 antibody

Rabbit Polyclonal to Human ZNF521

Cat. Num. AAA243137

• Gene Names: ZNF521; EHZF; Evi3
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: ZNF521; Polyclonal Antibody; Rabbit Polyclonal to Human ZNF521; Anti-ZNF521 Antibody (C-Terminus) IHC-plus; Evi3; EHZF; Zinc finger protein 521; LIP3; LYST-interacting protein 3; Human ZNF521; anti-ZNF521 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1311

• Applicable Applications for anti-ZNF521 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (5 ug/ml)
• Target Species: Human
• Immunogen Description: A 19 amino acid peptide near the carboxy terminus of human ZNF521.
• Immunogen Type: Synthetic peptide
• Immunogen: ZNF521 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human ZNF521.
• Antigen Modification: C-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-ZNF521 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-ZNF521 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 24308069
• NCBI GeneID: 25925
• NCBI Accession #: NP_056276.1
• NCBI GenBank Nucleotide #: NM_015461.2
• UniProt Accession #: Q96K83; Q8IXI0; Q8TES6; Q9C065; Q9HAL5; Q9UFK4; A3QVP7; B0YJB7
• Molecular Weight: 147,866 Da
• NCBI Official Full Name: zinc finger protein 521
• NCBI Official Synonym Full Names: zinc finger protein 521
• NCBI Official Symbol: ZNF521
• NCBI Official Synonym Symbols: EHZF; Evi3
• NCBI Protein Information: zinc finger protein 521; LYST-interacting protein 3; early hematopoietic zinc finger protein
• UniProt Protein Name: Zinc finger protein 521
• Protein Family: Zinc finger protein
• UniProt Gene Name: ZNF521
• UniProt Synonym Gene Names: EHZF; LIP3
• UniProt Entry Name: ZN521_HUMAN

Uniprot Description

ZNF521: Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. A chromosomal aberration involving ZNF521 is found in acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with PAX5. The translocation generates the PAX5-ZNF521 oncogene consisting of the N-terminus part of PAX5 and the C-terminus part of ZNF521. Belongs to the krueppel C2H2-type zinc-finger protein family.

Protein type: DNA-binding; C2H2-type zinc finger protein; Transcription, coactivator/corepressor; Oncoprotein

Chromosomal Location of Human Ortholog: 18q11.2

Cellular Component: nucleus

Molecular Function: protein domain specific binding; DNA binding; metal ion binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; multicellular organismal development; cell differentiation