Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using ZNF143 Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200))
Rabbit ZNF143 Polyclonal Antibody | anti-ZNF143 antibody
ZNF143 Antibody
Gene Names
ZNF143; SBF; STAF; pHZ-1
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
ZNF143; Polyclonal Antibody; ZNF143 Antibody; SBF; STAF; pHZ-1; anti-ZNF143 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total ZNF143 protein.
Purity/Purification
Antigen affinity purification
Form/Format
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
0.2mg/ml (varies by lot)
Sequence Length
637
Applicable Applications for anti-ZNF143 antibody
Immunohistochemistry (IHC)
Application Notes
Immunohistochemistry: 1: 10-50
Immunogen
Synthetic peptide of human ZNF143
Immunogen Type
Peptide
Preparation and Storage
Store at -20 degree C
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using ZNF143 Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using ZNF143 Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200))
Related Product Information for anti-ZNF143 antibody
ZNF143 (zinc finger protein 143), also known as SBF, STAF or pHZ-1, is a 626 amino acid protein that contains seven C2H2-type zinc fingers and belongs to the GLI (glioma-associated oncogene) C2H2-type zinc-finger family. Localized to the nucleus and expressed ubiquitously with highest expression in ovaries, ZNF143 functions as a transcriptional activator that, via its C2H2-type zinc domains, binds to the SPH motif found in the promotors of small nuclear RNAs (snRNA). Through its ability to bind the promotors of various snRNA genes, ZNF143 controls the subsequent expression of the corresponding protein products. ZNF143 expression is induced upon DNA damage, suggesting an important role for ZNF143 in DNA repair events.
Product Categories/Family for anti-ZNF143 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
68,894 Da
NCBI Official Full Name
zinc finger protein 143 isoform 2
NCBI Official Synonym Full Names
zinc finger protein 143
NCBI Official Symbol
ZNF143
NCBI Official Synonym Symbols
SBF; STAF; pHZ-1
NCBI Protein Information
zinc finger protein 143
UniProt Protein Name
Zinc finger protein 143
Protein Family
UniProt Gene Name
ZNF143
UniProt Synonym Gene Names
SBF; STAF; hStaf
UniProt Entry Name
ZN143_HUMAN
Uniprot Description
ZNF143: a transcriptional activator that binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Interacts with p73. Involved in cisplatin resistance through the transcriptional regulation of DNA repair genes. Transcriptional tergets include BUB1B, TFAM and transaldolase. Association with CHD8 contributes to efficient U6 RNA polymerase III transcription.
Protein type: C2H2-type zinc finger protein; Transcription factor
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: nucleoplasm
Molecular Function: protein binding
Biological Process: regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase III promoter; snRNA transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription from RNA polymerase III promoter
Research Articles on ZNF143
Similar Products
Product Notes
The ZNF143 znf143 (Catalog #AAA9417206) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ZNF143 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ZNF143 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1: 10-50. Researchers should empirically determine the suitability of the ZNF143 znf143 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZNF143, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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