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Western Blot (WB) (ZMYND10 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ZMYND10 antibody detected the ZMYND10 protein (arrow).)

Rabbit anti-Human ZMYND10 Polyclonal Antibody | anti-ZMYND10 antibody

ZMYND10 Antibody (Center)

Gene Names
ZMYND10; BLU; FLU; CILD22
Reactivity
Human
Applications
Western Blot, ELISA, Immunohistochemistry, Flow Cytometry, Functional Assay
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
ZMYND10; Polyclonal Antibody; ZMYND10 Antibody (Center); Zinc finger MYND domain-containing protein 10; Protein BLu; BLU; anti-ZMYND10 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This ZMYND10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 321-348 amino acids from the Central region of human ZMYND10.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
321-348
Sequence Length
440
Applicable Applications for anti-ZMYND10 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(ZMYND10 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ZMYND10 antibody detected the ZMYND10 protein (arrow).)

Western Blot (WB) (ZMYND10 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ZMYND10 antibody detected the ZMYND10 protein (arrow).)

Immunohistochemistry (IHC)

(ZMYND10 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ZMYND10 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Immunohistochemistry (IHC) (ZMYND10 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ZMYND10 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Flow Cytometry (FC/FACS)

(ZMYND10 Antibody (Center) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

Flow Cytometry (FC/FACS) (ZMYND10 Antibody (Center) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Related Product Information for anti-ZMYND10 antibody
BLU is a candidate tumor suppressor gene, that spans 4.5 kb on 3p21.3. It encodes a 50 kd protein, which is commonly found in transcription repressors. It is suspected that BLU has a function in cell cycle progression. BLU is a stress-responsive gene regulated by E2F.12 It is commonly found to be downregulated in non-small cell lung cancer, esophagus squamous cell carcinoma and nasopharyngeal carcinoma (NPC).
References
Shao, Y., et al. Cancer Invest. 28(6):642-648(2010)
Lorente, A., et al. Brain Pathol. 19(2):279-292(2009)
Muzny, D.M., et al. Nature 440(7088):1194-1198(2006)
Marsit, C.J., et al. Int. J. Cancer 114(2):219-223(2005)
Qiu, G.H., et al. Oncogene 23(27):4793-4806(2004)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
50344
NCBI Official Full Name
zinc finger MYND domain-containing protein 10 isoform 1
NCBI Official Synonym Full Names
zinc finger, MYND-type containing 10
NCBI Official Symbol
ZMYND10
NCBI Official Synonym Symbols
BLU; FLU; CILD22
NCBI Protein Information
zinc finger MYND domain-containing protein 10
UniProt Protein Name
Zinc finger MYND domain-containing protein 10
UniProt Gene Name
ZMYND10
UniProt Synonym Gene Names
BLU
UniProt Entry Name
ZMY10_HUMAN

NCBI Description

This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Uniprot Description

ZMYND10: 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: cytoplasm

Molecular Function: protein binding; metal ion binding

Disease: Ciliary Dyskinesia, Primary, 22

Research Articles on ZMYND10

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Product Notes

The ZMYND10 zmynd10 (Catalog #AAA9207926) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 321-348. The ZMYND10 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ZMYND10 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the ZMYND10 zmynd10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZMYND10, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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