Western Blot (WB)
(Western blot analysis of ZIP12 in HepG2 cell lysate with ZIP12 antibody at (A) 0.5 and (B) 1 μg/mL.)
Rabbit anti-Human, Mouse ZIP12 Polyclonal Antibody | anti-Slc39a12 antibody
ZIP12 Antibody
Gene Names
SLC39A12; ZIP-12; LZT-Hs8; bA570F3.1
Reactivity
Human, Mouse
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
ZIP12 Antibody is affinity chromatography purified via peptide column.
Synonyms
ZIP12; Polyclonal Antibody; ZIP12 Antibody; ZIP-12; LZT-Hs8; bA570F3.1; Zinc transporter ZIP12; LIV-1 subfamily of ZIP zinc transporter 8; solute carrier family 39 (zinc transporter); member 12; anti-Slc39a12 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
At least four isoforms of ZIP12 are known to exist. ZIP12 antibody is predicted to not cross-react with other ZIP family members.
Purity/Purification
ZIP12 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
691
Applicable Applications for anti-Slc39a12 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
ZIP12 antibody can be used for detection of ZIP12 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
Conjugate
Unconjugated
Immunogen
ZIP12 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human ZIP12.
Buffer
ZIP12 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
ZIP12 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of ZIP12 in HepG2 cell lysate with ZIP12 antibody at (A) 0.5 and (B) 1 μg/mL.)
Western Blot (WB)
(Western blot analysis of ZIP12 in HepG2 cell lysate with ZIP12 antibody at (A) 0.5 and (B) 1 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of ZIP12 in mouse liver tissue with ZIP12 antibody at 2.5 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of ZIP12 in mouse liver tissue with ZIP12 antibody at 2.5 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of ZIP12 in mouse liver tissue with ZIP12 antibody at 20 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of ZIP12 in mouse liver tissue with ZIP12 antibody at 20 μg/mL.)
Related Product Information for anti-Slc39a12 antibody
ZIP12 Antibody: The zinc transporter ZIP12, also known as SLC39A12, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP12 is a multipass membrane protein that belongs to the ZIP transporter subfamily LIV-1. Increased levels of ZIP12 have been observed during acute inflammation in the airway and asthma, suggesting that it may be promote increased zinc uptake, as this can reduce inflammation. The zinc content in brains in individuals with schizophrenia is lower than in individuals with other cerebral diseases, and mutations in ZIP12 have been observed in a small group of schizophrenic patients, suggesting that ZIP12 may play a role in this disease.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
76,538 Da
NCBI Official Full Name
zinc transporter ZIP12 isoform 1
NCBI Official Synonym Full Names
solute carrier family 39 (zinc transporter), member 12
NCBI Official Symbol
SLC39A12
NCBI Official Synonym Symbols
ZIP-12; LZT-Hs8; bA570F3.1
NCBI Protein Information
zinc transporter ZIP12; zrt- and Irt-like protein 12; solute carrier family 39 member 12; LIV-1 subfamily of ZIP zinc transporter 8; solute carrier family 39 (metal ion transporter), member 12
UniProt Protein Name
Zinc transporter ZIP12
Protein Family
UniProt Gene Name
SLC39A12
UniProt Synonym Gene Names
ZIP12; LZT-Hs8; ZIP-12
UniProt Entry Name
S39AC_HUMAN
NCBI Description
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A12 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Aug 2008]
Uniprot Description
SLC39A12: Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia. Belongs to the ZIP transporter (TC 2.A.5) family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 10p12.33
Cellular Component: perinuclear region of cytoplasm; integral to membrane; plasma membrane; vesicle
Molecular Function: zinc ion transmembrane transporter activity
Biological Process: signal transduction; regulation of microtubule polymerization
Research Articles on Slc39a12
Similar Products
Product Notes
The Slc39a12 slc39a12 (Catalog #AAA151136) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ZIP12 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ZIP12 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). ZIP12 antibody can be used for detection of ZIP12 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the Slc39a12 slc39a12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZIP12, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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