Rabbit anti-Human ZDHC7 Polyclonal Antibody | anti-ZDHC7 antibody

ZDHC7, CT (ZDHHC7, ZNF370, Palmitoyltransferase ZDHHC7, Zinc finger DHHC domain-containing protein 7, Zinc finger protein 370) (PE)

Cat. Num. AAA6365006

• Gene Names: ZDHHC7; DHHC7; SERZ1; SERZ-B; ZNF370
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ZDHC7; Polyclonal Antibody; CT (ZDHHC7; ZNF370; Palmitoyltransferase ZDHHC7; Zinc finger DHHC domain-containing protein 7; Zinc finger protein 370) (PE); ZDHHC7; Zinc finger protein 370; anti-ZDHC7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-ZDHC7 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: ZDHC7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-267 amino acids from the C-terminal region of human ZDHC7.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(ZDHC7 Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the ZDHC7 antibody detected the ZDHC7 protein (arrow).)

Related Product Information for anti-ZDHC7 antibody

Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and regulate their synaptic clustering and/or cell surface stability (By similarity).

Product Categories/Family for anti-ZDHC7 antibody

Antibodies; Transcription Factors; Zinc (Ring) Finger

References

Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008). Lehner, B., et al. Genomics 83(1):153-167(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 224493964
• NCBI GeneID: 55625
• NCBI Accession #: NP_001139020.1; NP_060210.2
• NCBI GenBank Nucleotide #: NM_001145548.1
• UniProt Accession #: Q9NXF8; Q8WV42; Q9NVD8; D3DUM1
• Molecular Weight: 35,140 Da
• NCBI Official Full Name: palmitoyltransferase ZDHHC7 isoform 1
• NCBI Official Synonym Full Names: zinc finger, DHHC-type containing 7
• NCBI Official Symbol: ZDHHC7
• NCBI Official Synonym Symbols: DHHC7; SERZ1; SERZ-B; ZNF370
• NCBI Protein Information: palmitoyltransferase ZDHHC7; DHHC-7; zinc finger protein 370; zinc finger, DHHC domain containing 7; zinc finger DHHC domain-containing protein 7; Sertoli cell gene with zinc finger domain-&#946
• UniProt Protein Name: Palmitoyltransferase ZDHHC7
• UniProt Gene Name: ZDHHC7
• UniProt Synonym Gene Names: ZNF370; DHHC-7
• UniProt Entry Name: ZDHC7_HUMAN

Uniprot Description

ZDHHC7: Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability. Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors. Belongs to the DHHC palmitoyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Palmitoyltransferase; EC 2.3.1.225; Membrane protein, integral; Transferase; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; integral to membrane; nucleolus; nucleus

Molecular Function: zinc ion binding; palmitoyltransferase activity; protein-cysteine S-palmitoleyltransferase activity

Biological Process: peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine; protein palmitoylation