Rabbit anti-Human, Rat ZBTB38 Polyclonal Antibody | anti-ZBTB38 antibody
ZBTB38 Antibody
Gene Names
ZBTB38; CIBZ; ZNF921; PPP1R171
Reactivity
Human, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
ZBTB38; Polyclonal Antibody; ZBTB38 Antibody; CIBZ; FLJ22332; FLJ31131; FLJ35036; ZBT38_HUMAN; Ziinc finger and BTB domain containing protein 38; Zinc finger and BTB domain-containing protein 38; anti-ZBTB38 antibody
Host
Rabbit
Reactivity
Human, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
ZBTB38 Antibody detects endogenous levels of ZBTB38.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-ZBTB38 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human ZBTB38.
Conjugation
Unconjugated
Similarity
The BTB domain is not required for activation of transcription or self-association.
Post Translational Modifications
Ubiquitinated by RBBP6; leading to its degradation by the proteasome.
Subunit Structure
Interacts with CBFA2T3. Interacts with ZBTB4. Interacts with RBBP6.
Function
Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner. Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication. Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).
Note
Localizes to chromocenters.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-ZBTB38 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
1195
NCBI Official Full Name
Zinc finger and BTB domain-containing protein 38
NCBI Official Synonym Full Names
zinc finger and BTB domain containing 38
NCBI Official Symbol
ZBTB38
NCBI Official Synonym Symbols
CIBZ; ZNF921; PPP1R171
NCBI Protein Information
zinc finger and BTB domain-containing protein 38; ZBTB38; protein phosphatase 1, regulatory subunit 171
UniProt Protein Name
Zinc finger and BTB domain-containing protein 38
Protein Family
UniProt Gene Name
ZBTB38
UniProt Entry Name
ZBT38_HUMAN
NCBI Description
The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with apoptosis in some cell types. [provided by RefSeq, Jun 2010]
Uniprot Description
ZBTB38: Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons.
Protein type: C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 3q23
Cellular Component: nucleus
Molecular Function: protein binding; protein homodimerization activity; methyl-CpG binding; metal ion binding; transcription factor activity
Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Disease: Stature Quantitative Trait Locus 10
Research Articles on ZBTB38
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Product Notes
The ZBTB38 zbtb38 (Catalog #AAA9630924) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ZBTB38 Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ZBTB38 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the ZBTB38 zbtb38 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZBTB38, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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