Western Blot (WB)
(Western blot analysis of anti-YY1 Ctr Pab in HL60 cell lysate (lane 1) and in mouse kidney tissue lysate (lane 2). YY1 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.)
Rabbit anti-Human, mouse YY1 Polyclonal Antibody | anti-YY1 antibody
YY1 Antibody (Center)
Western Blot (WB)
(Western blot analysis of anti-YY1 Ctr Pab in HL60 cell lysate (lane 1) and in mouse kidney tissue lysate (lane 2). YY1 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.)
Western Blot (WB)
(Western blot analysis of anti-YY1 Ctr Pab in HL60 cell lysate (lane 1) and in mouse kidney tissue lysate (lane 2). YY1 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Kurisaki, K., et al., Mol. Cell. Biol. 23(13):4494-4510 (2003).
Huang, N.E., et al., Biochem. Biophys. Res. Commun. 306(1):267-275 (2003).
Moriuchi, M., et al., J. Biol. Chem. 278(15):13003-13007 (2003).
Hiromura, M., et al., J. Biol. Chem. 278(16):14046-14052 (2003).
NCBI and Uniprot Product Information
NCBI Description
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]
Uniprot Description
YY1: a polycomb-group (Pc-G) protein essential for early mammalian development and the regulation of X-inactivation and certain imprinted genes. Required for the transactivation of TSIX by CTCF. The complex of CTCF-YY1-TSIX is a critical regulator of the X chromosome binary switch. Can function as an activator or a repressor depending on the presence of other proteins. For example it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence.
Protein type: Cell development/differentiation; C2H2-type zinc finger protein; Transcription factor
Chromosomal Location of Human Ortholog: 14q
Cellular Component: transcription factor complex; nuclear matrix; PcG protein complex; nucleus
Molecular Function: protein binding; four-way junction DNA binding; DNA binding; zinc ion binding; RNA binding; transcription coactivator activity; SMAD binding; transcription corepressor activity; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; anterior/posterior pattern formation; RNA localization; camera-type eye morphogenesis; transcription, DNA-dependent; spermatogenesis; negative regulation of transcription from RNA polymerase II promoter; cell differentiation; response to DNA damage stimulus; chromosome organization and biogenesis; response to UV-C; double-strand break repair via homologous recombination
Research Articles on YY1
Similar Products
Product Notes
The YY1 yy1 (Catalog #AAA9204427) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 268-297. The YY1 Antibody (Center) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's YY1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the YY1 yy1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "YY1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
