Rabbit anti-Human XPR1 Polyclonal Antibody | anti-XPR1 antibody

XPR1, NT (XPR1, SYG1, XR, Xenotropic and polytropic retrovirus receptor 1, Protein SYG1 homolog, Xenotropic and polytropic murine leukemia virus receptor X3) (FITC)

Cat. Num. AAA6364042

• Gene Names: XPR1; X3; SYG1; IBGC6; SLC53A1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: XPR1; Polyclonal Antibody; NT (XPR1; SYG1; XR; Xenotropic and polytropic retrovirus receptor 1; Protein SYG1 homolog; Xenotropic and polytropic murine leukemia virus receptor X3) (FITC); Xenotropic and polytropic murine leukemia virus receptor X3; anti-XPR1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-XPR1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: XPR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-122 amino acids from the N-terminal region of human XPR1.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(XPR1 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the XPR1 Antibody detected the XPR1 protein (arrow).)

Related Product Information for anti-XPR1 antibody

XPR1 may function in G-protein coupled signal transduction (By similarity). Potential receptor for xenotropic and polytropic murine leukemia retroviruses.

Product Categories/Family for anti-XPR1 antibody

Antibodies; Cancer Markers; Leukemia

References

Bhosle, S., et al. J. Virol. 84(13):6288-6296(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Battini, J.L., et al. Proc. Natl. Acad. Sci. U.S.A. 96(4):1385-1390(1999). Tailor, C.S., et al. Proc. Natl. Acad. Sci. U.S.A. 96(3):927-932(1999). Yang, Y.L., et al. Nat. Genet. 21(2):216-219(1999).

NCBI and Uniprot Product Information

• NCBI GI #: 208609982
• NCBI GeneID: 9213
• NCBI Accession #: NP_001129141.1
• NCBI GenBank Nucleotide #: NM_001135669.1
• UniProt Accession #: Q9UBH6; O95719; Q7L8K9; Q8IW20; Q9NT19; Q9UFB9
• Molecular Weight: 73,919 Da
• NCBI Official Full Name: xenotropic and polytropic retrovirus receptor 1 isoform 2
• NCBI Official Synonym Full Names: xenotropic and polytropic retrovirus receptor 1
• NCBI Official Symbol: XPR1
• NCBI Official Synonym Symbols: X3; SYG1; IBGC6; SLC53A1
• NCBI Protein Information: xenotropic and polytropic retrovirus receptor 1
• UniProt Protein Name: Xenotropic and polytropic retrovirus receptor 1
• Protein Family: Xenotropic and polytropic retrovirus receptor
• UniProt Gene Name: XPR1
• UniProt Synonym Gene Names: SYG1; XR; X-receptor
• UniProt Entry Name: XPR1_HUMAN

NCBI Description

The protein encoded by this gene is a receptor for the xenotropic and polytropic classes of murine leukemia viruses. The encoded protein is involved in phosphate homeostasis by mediating phosphate export from the cell. Defects in this gene have been associated with idiopathic basal ganglia calcification-6. [provided by RefSeq, Jun 2016]

Uniprot Description

XPR1: May function in G-protein coupled signal transduction. Potential receptor for xenotropic and polytropic murine leukemia retroviruses. Belongs to the SYG1 (TC 2.A.94) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q25.1

Cellular Component: Golgi apparatus; integral to plasma membrane; plasma membrane

Molecular Function: viral receptor activity; G-protein coupled receptor activity; transmembrane receptor activity; receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; entry of virus into host cell; response to virus

Disease: Basal Ganglia Calcification, Idiopathic, 6