Rabbit anti-Human, Mouse XPO7 Polyclonal Antibody | anti-XPO7 antibody

XPO7 Antibody

Cat. Num. AAA9630134

• Gene Names: XPO7; EXP7; RANBP16
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: XPO7; Polyclonal Antibody; XPO7 Antibody; Exp 7; Exp7; Exportin 7; Exportin7; KIAA0745; RAN binding protein 16; RANBP 16; XPO 7; anti-XPO7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: XPO7 Antibody detects endogenous levels of XPO7.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-XPO7 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human XPO7.
• Conjugation: Unconjugated
• Similarity: Belongs to the exportin family.
• Subunit Structure: Binds to nucleoporins. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with ARHGAP1 and SFN. Interacts with Ran and cargo proteins in a GTP-dependent manner.
• Tissue Specificity: Strong expression in testis, thyroid and bone marrow, low expression in lung, liver and small intestine, no expression in thymus, and remaining tissues studied have moderate expression. Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology.
• Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
• Note: huttles between the nucleus and the cytoplasm.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-XPO7 antibody

Cytoplasm; Nucleus; Nuclear pore complex; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 154448892
• NCBI GeneID: 23039
• NCBI Accession #: NP_055839.3
• NCBI GenBank Nucleotide #: NM_015024.4
• UniProt Accession #: Q9UIA9; O94846; Q6PJK9; Q8NEK7
• Molecular Weight: 123,907 Da
• NCBI Official Full Name: exportin-7
• NCBI Official Synonym Full Names: exportin 7
• NCBI Official Symbol: XPO7
• NCBI Official Synonym Symbols: EXP7; RANBP16
• NCBI Protein Information: exportin-7; RAN binding protein 16
• UniProt Protein Name: Exportin-7
• Protein Family: Exportin
• UniProt Gene Name: XPO7
• UniProt Synonym Gene Names: KIAA0745; RANBP16; Exp7
• UniProt Entry Name: XPO7_HUMAN

NCBI Description

The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]

Uniprot Description

Exportin-7: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the exportin family.

Protein type: Nuclear export; Nuclear import; Karyopherin

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: cytoplasm; nuclear pore; nucleus

Molecular Function: nuclear export signal receptor activity; Ran GTPase binding

Biological Process: mRNA transport; protein export from nucleus