Western Blot (WB)
(Western Blot analysis of XPA polyclonal antibody)
Rabbit anti-Human, Mouse XPA Polyclonal Antibody | anti-XPA antibody
XPA Polyclonal Antibody
IF: 1:50-1:100
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot analysis of XPA polyclonal antibody)
Western Blot (WB)
(Western Blot analysis of XPA polyclonal antibody)
Western Blot (WB)
(Western Blot analysis of extracts from normal (control) and XPA knockout (KO) HeLa cells, using XPA antibody.)
Western Blot (WB)
(Western Blot analysis of extracts from normal (control) and XPA knockout (KO) HeLa cells, using XPA antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of GFP-RNF168 transgenic U2OS cells using XPA antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of GFP-RNF168 transgenic U2OS cells using XPA antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017]
Uniprot Description
XPA: Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. Interacts with GPN1 and RPA1. Interacts (via N-terminus) with CEP164 upon UV irradiation. Interacts with HERC2. Expressed in various cell lines and in skin fibroblasts. Belongs to the XPA family.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 9q22.3
Cellular Component: nucleoplasm; Golgi apparatus; intercellular bridge; DNA replication factor A complex; cytoplasm; nucleus
Molecular Function: protein domain specific binding; protein binding; protein homodimerization activity; metal ion binding; damaged DNA binding
Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; nucleotide-excision repair; response to toxin; multicellular organism growth; nucleotide-excision repair, DNA damage removal; response to oxidative stress; DNA repair; response to UV
Disease: Xeroderma Pigmentosum, Complementation Group A
Research Articles on XPA
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Product Notes
The XPA xpa (Catalog #AAA3008182) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The XPA Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's XPA can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). WB: 1:500-1:2000 IF: 1:50-1:100. Researchers should empirically determine the suitability of the XPA xpa for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "XPA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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