Rabbit anti-Human X11gamma Polyclonal Antibody | anti-X11gamma antibody

X11gamma (R401) Polyclonal Antibody

Cat. Num. AAA3004318

• Gene Names: APBA3; X11L2; mint3; MGC:15815
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: X11gamma; Polyclonal Antibody; X11gamma (R401) Polyclonal Antibody; Amyloid beta A4 precursor protein-binding family A member 3; Adapter protein X11gamma; Neuron-specific X11L2 protein; Neuronal Munc18-1-interacting protein 3; Mint-3; APBA3; MINT3; X11L2; anti-X11gamma antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: X11gamma (R401) polyclonal antibody detects endogenous levels of X11gamma protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 575

• Applicable Applications for anti-X11gamma antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 371-420 of Human X11gamma.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of X11gamma (R401) pAb in paraffin-embedded human lung carcinoma tissue at 1:100.)

Related Product Information for anti-X11gamma antibody

Amyloid beta precursor protein (beta APP) is a major constituent of the amyloid deposits in patients with Alzheimer's disease. The amyloid beta precursor is known to interact with several proteins, including the G heterotrimetric protein, APP-BP1, and X11. The neuronal, transmembrane protein X11 is known to bind to the amyloid beta precurser protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular beta APP and slowing beta APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of beta APP. Multiple splice varitents of X11 have been identified, including X11 alpha, beta and gamma (also known as Mint 1, 2 and 3, respectively).

NCBI and Uniprot Product Information

• NCBI GI #: 11342678
• NCBI GeneID: 9546
• NCBI Accession #: NP_004877.1
• NCBI GenBank Nucleotide #: NP_004877.1
• UniProt Accession #: O96018
• Molecular Weight: ~ 61kDa
• NCBI Official Full Name: amyloid-beta A4 protein-binding family A member 3
• NCBI Official Synonym Full Names: amyloid beta precursor protein binding family A member 3
• NCBI Official Symbol: APBA3
• NCBI Official Synonym Symbols: X11L2; mint3; MGC:15815
• NCBI Protein Information: amyloid-beta A4 precursor protein-binding family A member 3
• UniProt Protein Name: Amyloid beta A4 precursor protein-binding family A member 3
• UniProt Gene Name: APBA3
• UniProt Synonym Gene Names: MINT3; X11L2; Mint-3
• UniProt Entry Name: APBA3_HUMAN

NCBI Description

The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease. [provided by RefSeq, Jul 2008]

Uniprot Description

APBA3: May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: perinuclear region of cytoplasm

Molecular Function: enzyme inhibitor activity; protein binding; enzyme binding; beta-amyloid binding

Biological Process: synaptic transmission; protein transport; regulation of gene expression; in utero embryonic development; negative regulation of catalytic activity