Rabbit anti-Human WRB Polyclonal Antibody | anti-WRB antibody

WRB Antibody

Cat. Num. AAA7045921

• Gene Names: WRB; CHD5; GET1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: >95%, Protein G purified
• Synonyms: WRB; Polyclonal Antibody; WRB Antibody; Tail-anchored protein insertion receptor WRB; Congenital heart disease 5 protein; Tryptophan-rich basic protein; CHD5; anti-WRB antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 140

• Applicable Applications for anti-WRB antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Species: Human
• Immunogen: Recombinant human Tail-anchored protein insertion receptor WRB protein
• Conjugate: Non-conjugated
• Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-83350
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western BlotPositive WB detected in:Mouse spleen tissueAll lanes: WRB antibody at 3.4ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 20,17 kDaObserved band size: 20 kDa)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded MBS7045921 using human testis tissue at dilution 1:100)

Immunohistochemistry (IHC)

(Immunofluorescent analysis of Hela cells using MBS7045921 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Related Product Information for anti-WRB antibody

Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.

NCBI and Uniprot Product Information

• NCBI GI #: 226246630
• NCBI GeneID: 7485
• NCBI Accession #: NP_001139690.1
• NCBI GenBank Nucleotide #: NM_001146218.1
• UniProt Accession #: O00258; O60740; A8KAP8; A8MQ44; D3DSH9
• Molecular Weight: 16,011 Da
• NCBI Official Full Name: tail-anchored protein insertion receptor WRB isoform 2
• NCBI Official Synonym Full Names: tryptophan rich basic protein
• NCBI Official Symbol: WRB
• NCBI Official Synonym Symbols: CHD5; GET1
• NCBI Protein Information: tail-anchored protein insertion receptor WRB
• UniProt Protein Name: Tail-anchored protein insertion receptor WRB
• Protein Family: Tail-anchored protein insertion receptor
• UniProt Gene Name: WRB
• UniProt Synonym Gene Names: CHD5; WRB
• UniProt Entry Name: WRB_HUMAN

NCBI Description

This gene encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome (DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Uniprot Description

WRB: Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane. Belongs to the WRB/GET1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: nucleus