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Rabbit anti-Human WNK1 Polyclonal Antibody | anti-WNK1 antibody

WNK1 antibody

Gene Names
Wnk1; Hsn2; Prkwnk1; EG406236; mKIAA0344; 6430573H23Rik
Reactivity
Human
Applications
Immunohistochemistry
Purity
WNK1 antibody was purified by affinity chromatography.
Synonyms
WNK1; Polyclonal Antibody; WNK1 antibody; Polyclonal WNK1; Anti-WNK1; WNK 1; wnk1; KIAA0344; kinase deficient protein; protein kinase lysine deficient 1; prkwnk1; WNK -1; PSEUDOHYPOALDOSTERONISM TYPE IIC; PHA2C; Kdp; anti-WNK1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
Human
Purity/Purification
WNK1 antibody was purified by affinity chromatography.
Form/Format
Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1% NaN3.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
2377
Applicable Applications for anti-WNK1 antibody
Immunohistochemistry (IHC) Paraffin
Application Notes
IHC-P: 4 ug/ml
Biological Significance
WNK lysine deficient protein kinase 1, also known as WNK1, is an enzyme which in humans is encoded by the WNK1 gene. The human gene is located on short arm of chromosome 12 (12p13.3). WNK1 is also known as Human Accelerated Region 5. It may, therefore, have played a key role in differentiating Humans from Apes. The WNK1 gene encodes a cytoplasmic serine-threonine kinase expressed in the distal nephron.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
Immunogen
WNK1 antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Related Product Information for anti-WNK1 antibody
Rabbit polyclonal WNK1 antibody
Product Categories/Family for anti-WNK1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
86,037 Da
NCBI Official Full Name
WNK1
NCBI Official Synonym Full Names
WNK lysine deficient protein kinase 1
NCBI Official Symbol
Wnk1
NCBI Official Synonym Symbols
Hsn2; Prkwnk1; EG406236; mKIAA0344; 6430573H23Rik
NCBI Protein Information
serine/threonine-protein kinase WNK1
UniProt Protein Name
Serine/threonine-protein kinase WNK1
UniProt Gene Name
Wnk1
UniProt Synonym Gene Names
Hsn2; Prkwnk1
UniProt Entry Name
WNK1_MOUSE

Uniprot Description

WNK1: a serine-threonine protein kinase that controls sodium and chloride ion transport. May regulate the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation. May also play a role in actin cytoskeletal reorganization.

Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; Wnk family

Cellular Component: cytoplasm

Molecular Function: protein kinase inhibitor activity; nucleotide binding; magnesium ion binding; protein kinase binding; protein kinase activity; phosphatase binding; protein serine/threonine kinase inhibitor activity; transferase activity; protein serine/threonine kinase activity; protein binding; chloride channel inhibitor activity; transferase activity, transferring phosphorus-containing groups; kinase activity; potassium channel inhibitor activity; ATP binding

Biological Process: negative regulation of kinase activity; protein amino acid autophosphorylation; regulation of cellular process; ion transport; positive regulation of systemic arterial blood pressure; protein amino acid phosphorylation; phosphorylation

Research Articles on WNK1

Similar Products

Product Notes

The WNK1 wnk1 (Catalog #AAA535685) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The WNK1 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's WNK1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin. IHC-P: 4 ug/ml. Researchers should empirically determine the suitability of the WNK1 wnk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "WNK1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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