Rabbit anti-Human Wingless Type MMTV Integration Site Family, Member 3A (WNT3A) Polyclonal Antibody | anti-WNT3A antibody

HRP-Linked Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)

Reactivity

Human

Applications

Western Blot, Immunocytochemistry, Immunohistochemistry, ELISA

Synonyms

Wingless Type MMTV Integration Site Family; Member 3A (WNT3A); Polyclonal Antibody; HRP-Linked Polyclonal Antibody to Wingless Type MMTV Integration Site Family; anti-WNT3A antibody

Ordering
Cat. Num. AAA2084374 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Concentration

500ug/ml (varies by lot)

Applicable Applications for anti-WNT3A antibody

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)

Immunogen

WNT3A (Ser19~Lys352)

Conjugation

HRP

Cross Reactivity

Human, Bovine

Unconjugated Antibody

The unconjugated antibody version of this item is also available as catalog #MBS2028014

NCBI and Uniprot Product Information

NCBI GI #

119590235

NCBI GeneID

89780

Molecular Weight

42,905 Da

NCBI Official Full Name

wingless-type MMTV integration site family, member 3A

NCBI Official Synonym Full Names

Wnt family member 3A

NCBI Official Symbol

WNT3A

NCBI Protein Information

protein Wnt-3a

UniProt Protein Name

Protein Wnt-3a

UniProt Gene Name

WNT3A

NCBI Description

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]

Uniprot Description

WNT3A: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube. Interacts with PORCN. Interacts with APCDD1 and WLS. Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6. Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate. Belongs to the Wnt family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: cell surface; early endosome membrane; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen; plasma membrane

Molecular Function: frizzled binding; protein binding; receptor agonist activity; receptor binding; transcription coactivator activity

Biological Process: cell proliferation in forebrain; cell proliferation in midbrain; negative regulation of neurogenesis; neuron differentiation; palate development; positive regulation of cell proliferation; positive regulation of mesodermal cell fate specification; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of protein binding; positive regulation of receptor internalization; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; signalosome assembly; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin

Research Articles on WNT3A

1. The level of Wnt3a expression in hepatocellular carcinoma(HCC) patients was obviously higher than that in any group of cases with benign liver diseases. The diagnostic specificity or the area under the receiver operating characteristic curve was 94.34 % or 0.994 in Wnt3a and 69.81 % or 0.710 in AFP for HCC, respectively.

Similar Products

Product Notes

The WNT3A wnt3a (Catalog #AAA2084374) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HRP-Linked Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Wingless Type MMTV Integration Site Family, Member 3A (WNT3A) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA). Researchers should empirically determine the suitability of the WNT3A wnt3a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Wingless Type MMTV Integration Site Family, Member 3A (WNT3A), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

Loading...