Rabbit anti-Mouse WBSCR17 Polyclonal Antibody | anti-WBSCR17 antibody

WBSCR17, CT (WBSCR17, GALNTL3, Putative polypeptide N-acetylgalactosaminyltransferase-like protein 3, Polypeptide GalNAc transferase-like protein 3, Protein-UDP acetylgalactosaminyltransferase-like protein 3, UDP-GalNAc:polypeptide N-acetylgalactosaminylt

Cat. Num. AAA6363052

• Gene Names: GALNT17; GALNT16; GALNT20; GALNTL3; WBSCR17; GALNACT17; GalNAc-T17; GalNAc-T19; GalNAc-T5L
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: WBSCR17; Polyclonal Antibody; CT (WBSCR17; GALNTL3; Putative polypeptide N-acetylgalactosaminyltransferase-like protein 3; Polypeptide GalNAc transferase-like protein 3; Protein-UDP acetylgalactosaminyltransferase-like protein 3; UDP-GalNAc:polypeptide N-acetylgalactosaminylt; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 3; Williams-Beuren syndrome chromosomal region 17 protein; anti-WBSCR17 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-WBSCR17 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: WBSCR17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-440 amino acids from the C-terminal region of human WBSCR17.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(WBSCR17 Antibody (C-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the WBSCR17 antibody detected the WBSCR17 protein (arrow).)

Related Product Information for anti-WBSCR17 antibody

This gene encodes an N-acetylgalactosaminyltransferase, which has 97% sequence identity to the mouse protein. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. [provided by RefSeq].

Product Categories/Family for anti-WBSCR17 antibody

Antibodies; Enzymes; Glycosyltransferase

References

Rose, J. Phd, et al. Mol. Med. (2010). In press: Trynka, G., et al. Gut 58(8):1078-1083(2009). Nakamura, N., et al. Biol. Pharm. Bull. 28(3):429-433(2005). Merla, G., et al. Hum. Genet. 110(5):429-438(2002). Valero, M.C., et al. Genomics 69(1):1-13(2000).

NCBI and Uniprot Product Information

• NCBI GI #: 22538495
• NCBI GeneID: 64409
• NCBI Accession #: NP_071924.1
• NCBI GenBank Nucleotide #: NM_022479.2
• UniProt Accession #: Q6IS24; Q8NFV9; Q9NTA8
• Molecular Weight: 67,751 Da
• NCBI Official Full Name: polypeptide N-acetylgalactosaminyltransferase 17
• NCBI Official Synonym Full Names: polypeptide N-acetylgalactosaminyltransferase 17
• NCBI Official Symbol: GALNT17
• NCBI Official Synonym Symbols: GALNT16; GALNT20; GALNTL3; WBSCR17; GALNACT17; GalNAc-T17; GalNAc-T19; GalNAc-T5L
• NCBI Protein Information: polypeptide N-acetylgalactosaminyltransferase 17; putative polypeptide N-acetylgalactosaminyltransferase-like protein 3
• UniProt Protein Name: Polypeptide N-acetylgalactosaminyltransferase 17
• Protein Family: Putative polypeptide N-acetylgalactosaminyltransferase-like protein
• UniProt Gene Name: GALNT17
• UniProt Synonym Gene Names: GalNAc-T-like protein 3; pp-GaNTase-like protein 3

NCBI Description

This gene encodes an N-acetylgalactosaminyltransferase. This gene is located centromeric to the common deleted region in Williams-Beuren syndrome (WBS), a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. This protein may play a role in membrane trafficking. [provided by RefSeq, Jan 2013]

Uniprot Description

WBSCR17: May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. WBSCR17 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.

Protein type: EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase

Chromosomal Location of Human Ortholog: 7q11.22

Cellular Component: Golgi membrane; integral component of membrane

Molecular Function: carbohydrate binding; metal ion binding; polypeptide N-acetylgalactosaminyltransferase activity

Biological Process: protein glycosylation