Rabbit anti-Human WASF3 Polyclonal Antibody | anti-WASF3 antibody

WASF3 Antibody

Cat. Num. AAA7132512

• Gene Names: WASF3; SCAR3; WAVE3; Brush-1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: WASF3; Polyclonal Antibody; WASF3 Antibody; Wiskott-Aldrich syndrome protein family member 3; WASP family protein member 3; Protein WAVE-3; Verprolin homology domain-containing protein 3; anti-WASF3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid; Rabbit IgG In Phosphate Buffered Saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol.

• Applicable Applications for anti-WASF3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:3000; IHC: 1:50-1:100
• Immunogen: Synthesized peptide derived from internal of human WASF3.
• Immunogen Species: Human
• Conjugate: Non-conjugated
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blot analysis of extracts from 3T3 cells and 293 cells, using WASF3 antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using WASF3antibody.)

Product Categories/Family for anti-WASF3 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 13699803
• NCBI GeneID: 10810
• NCBI Accession #: NP_006637.2
• NCBI GenBank Nucleotide #: NM_006646.5
• UniProt Accession #: Q9UPY6; O94974
• Molecular Weight: 55,293 Da
• NCBI Official Full Name: wiskott-Aldrich syndrome protein family member 3
• NCBI Official Synonym Full Names: WAS protein family, member 3
• NCBI Official Symbol: WASF3
• NCBI Official Synonym Symbols: SCAR3; WAVE3; Brush-1
• NCBI Protein Information: wiskott-Aldrich syndrome protein family member 3; protein WAVE-3; WASP family protein member 3; WASP family Verprolin-homologous protein 3; verprolin homology domain-containing protein 3
• UniProt Protein Name: Wiskott-Aldrich syndrome protein family member 3
• Protein Family: Wiskott-Aldrich syndrome protein family
• UniProt Gene Name: WASF3
• UniProt Synonym Gene Names: KIAA0900; SCAR3; WAVE3; WASP family protein member 3
• UniProt Entry Name: WASF3_HUMAN

NCBI Description

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. [provided by RefSeq, Jul 2008]

Uniprot Description

WASF3: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Binds actin and the Arp2/3 complex. Expressed in ovary and brain. Belongs to the SCAR/WAVE family.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: cytoskeleton; lamellipodium; cytoplasm

Molecular Function: actin binding

Biological Process: positive regulation of myelination; lamellipodium biogenesis; regulation of cell shape; actin filament polymerization; protein complex assembly; cytoskeleton organization and biogenesis; oligodendrocyte development