Rabbit anti-Human VSX2 Polyclonal Antibody | anti-VSX2 antibody

VSX2, CT (VSX2, CHX10, HOX10, Visual system homeobox 2, Ceh-10 homeodomain-containing homolog, Homeobox protein CHX10) (AP)

Cat. Num. AAA6362895

• Gene Names: VSX2; RET1; CHX10; HOX10; MCOP2; MCOPCB3
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: VSX2; Polyclonal Antibody; CT (VSX2; CHX10; HOX10; Visual system homeobox 2; Ceh-10 homeodomain-containing homolog; Homeobox protein CHX10) (AP); Homeobox protein CHX10; anti-VSX2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-VSX2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: VSX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-291 amino acids from the C-terminal region of human VSX2.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(VSX2 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the VSX2 antibody detected the VSX2 protein (arrow).)

Related Product Information for anti-VSX2 antibody

This gene encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities.

Product Categories/Family for anti-VSX2 antibody

Antibodies; Transcription Factors; Zinc; Ring; Homeobox

References

Gonzalez-Rodriguez, J., et al. Br J Ophthalmol 94(8):1100-1104(2010). Iseri, S.U., et al. Hum. Genet. 128(1):51-60(2010). Reichman, S., et al. Hum. Mol. Genet. 19(2):250-261(2010). Nagel, S., et al. Mol. Cancer 9, 151 (2010): Zhang, X., et al. Mol. Vis. 15, 2911-2918 (2009).

NCBI and Uniprot Product Information

• NCBI GI #: 34365783
• NCBI GeneID: 338917
• NCBI Accession #: NP_878314.1
• NCBI GenBank Nucleotide #: NM_182894.2
• UniProt Accession #: P58304; A1A4X6
• Molecular Weight: 39,411 Da
• NCBI Official Full Name: visual system homeobox 2
• NCBI Official Synonym Full Names: visual system homeobox 2
• NCBI Official Symbol: VSX2
• NCBI Official Synonym Symbols: RET1; CHX10; HOX10; MCOP2; MCOPCB3
• NCBI Protein Information: visual system homeobox 2; homeobox protein CHX10; ceh-10 homeodomain-containing homolog; ceh-10 homeo domain containing homolog
• UniProt Protein Name: Visual system homeobox 2
• Protein Family: Visual system homeobox
• UniProt Gene Name: VSX2
• UniProt Synonym Gene Names: CHX10; HOX10
• UniProt Entry Name: VSX2_HUMAN

Uniprot Description

Function: Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells

By similarity.

Subcellular location: Nucleus.

Tissue specificity: Abundantly expressed in retinal neuroblasts during eye development and in the inner nuclear layer of the adult retina. Within this layer, expression is stronger in the outer margin where bipolar cells predominate.

Involvement in disease: Microphthalmia, isolated, 2 (MCOP2) [MIM:610093]: A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6 Ref.7Microphthalmia with cataracts and iris abnormalities (MCOPCTI) [MIM:610092]: A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1Microphthalmia, isolated, with coloboma, 3 (MCOPCB3) [MIM:610092]: A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure).Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6

Sequence similarities: Belongs to the paired homeobox family.Contains 1 CVC domain.Contains 1 homeobox DNA-binding domain.