Rabbit anti-Human VSIG4 Polyclonal Antibody | anti-VSIG4 antibody

VSIG4 Antibody (C-term)

Cat. Num. AAA9215155

• Gene Names: VSIG4; CRIg; Z39IG
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: VSIG4; Polyclonal Antibody; VSIG4 Antibody (C-term); V-set and immunoglobulin domain-containing protein 4; Protein Z39Ig; CRIg; Z39IG; anti-VSIG4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This VSIG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-335 amino acids from the C-terminal region of human VSIG4.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Positions: 308-335
• Sequence Length: 305

• Applicable Applications for anti-VSIG4 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:1000
• Function: Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.
• Cellular Location: Membrane; Single-pass type I membrane protein
• Tissue Location: Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta Expressed in resting macrophages.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(VSIG4 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the VSIG4 antibody detected the VSIG4 protein (arrow).)

Related Product Information for anti-VSIG4 antibody

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq].

Product Categories/Family for anti-VSIG4 antibody

Immunology

References

Guo, S., et al. Clin. Immunol. 136(2):282-291(2010)
Van Loo, P., et al. Haematologica 95(3):440-448(2010)
Xu, S., et al. Immunol. Lett. 128(1):46-50(2010)
He, J.Q., et al. Mol. Immunol. 45(16):4041-4047(2008)
Vogt, L., et al. J. Clin. Invest. 116(10):2817-2826(2006)

NCBI and Uniprot Product Information

• NCBI GI #: 154426280
• NCBI GeneID: 11326
• NCBI Accession #: NP_001093901.1; NP_001171759.1; NP_001171760.1; NP_001244332.1; NP_009199.1
• NCBI GenBank Nucleotide #: NM_001100431.1
• UniProt Accession #: Q9Y279; Q6UXI4
• Molecular Weight: 43987
• NCBI Official Full Name: V-set and immunoglobulin domain-containing protein 4 isoform 2
• NCBI Official Synonym Full Names: V-set and immunoglobulin domain containing 4
• NCBI Official Symbol: VSIG4
• NCBI Official Synonym Symbols: CRIg; Z39IG
• NCBI Protein Information: V-set and immunoglobulin domain-containing protein 4
• UniProt Protein Name: V-set and immunoglobulin domain-containing protein 4
• Protein Family: V-set and immunoglobulin domain-containing protein
• UniProt Gene Name: VSIG4
• UniProt Synonym Gene Names: CRIg; Z39IG
• UniProt Entry Name: VSIG4_HUMAN

NCBI Description

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Uniprot Description

VSIG4: Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq12-q13.3

Cellular Component: integral to membrane

Molecular Function: protein binding

Biological Process: negative regulation of T cell proliferation; complement activation, alternative pathway; negative regulation of interleukin-2 production