Rabbit anti-Human VPS37C Polyclonal Antibody | anti-VPS37C antibody
VPS37C Antibody
Reactivity
Human
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
VPS37C; Polyclonal Antibody; VPS37C Antibody; 5730409F24Rik; AU042646; ESCRT I complex subunit VPS37C; ESCRT-I complex subunit VPS37C; FLJ20847; hVps37C; PML39; RGD1309258; Vacuolar protein sorting 37 homolog C (S. cerevisiae); Vacuolar protein sorting 37C (yeast); Vacuolar protein sorting 37C; Vacuolar protein sorting associated protein 37C; Vacuolar protein sorting-associated protein 37C; VP37C_HUMAN; anti-VPS37C antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
VPS37C Antibody detects endogenous levels of VPS37C.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-VPS37C antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human VPS37C.
Conjugation
Unconjugated
Similarity
Belongs to the VPS37 family.
Post Translational Modifications
Phosphorylated by TBK1.
Subunit Structure
Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with HGS and STAM2. Interacts with CEP55.
Function
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Note
Probably associates with membranes. Recruited to the plasma membrane by HIV-1.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-VPS37C antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
38,659 Da
NCBI Official Full Name
vacuolar protein sorting-associated protein 37C
NCBI Official Synonym Full Names
vacuolar protein sorting 37 homolog C (S. cerevisiae)
NCBI Official Symbol
VPS37C
NCBI Protein Information
vacuolar protein sorting-associated protein 37C; hVps37C; vacuolar protein sorting 37C; ESCRT-I complex subunit VPS37C
UniProt Protein Name
Vacuolar protein sorting-associated protein 37C
Protein Family
UniProt Gene Name
VPS37C
UniProt Synonym Gene Names
PML39; hVps37C
UniProt Entry Name
VP37C_HUMAN
NCBI Description
VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]
Uniprot Description
VPS37C: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Belongs to the VPS37 family.
Chromosomal Location of Human Ortholog: 11q12.2
Cellular Component: late endosome membrane; endosome membrane
Molecular Function: protein binding; calcium-dependent protein binding
Biological Process: protein transport; viral reproduction; viral protein processing; viral infectious cycle; virus assembly; endosome transport
Research Articles on VPS37C
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Product Notes
The VPS37C vps37c (Catalog #AAA9630132) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The VPS37C Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's VPS37C can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the VPS37C vps37c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VPS37C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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