Rabbit VPS24 Polyclonal Antibody | anti-VPS24 antibody

VPS24 Rabbit Polyclonal

Cat. Num. AAA7605663

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: VPS24; Polyclonal Antibody; VPS24 Rabbit Polyclonal; anti-VPS24 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 224

• Applicable Applications for anti-VPS24 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Immunogen: Vacuolar protein sorting 24 homolog (S. cerevisiae)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human heart using MBS7605663 (VPS24 antibody) at dilution of 1:50)

Immunofluorescence (IF)

(Immunofluorescent analysis of HepG2 cells using MBS7605663 (VPS24 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG (H+L))

Western Blot (WB)

(HEK-293 cells were subjected to SDS PAGE followed by western blot with MBS7605663 (VPS24 antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 486052
• UniProt Accession #: P36095; D6VXP5
• Molecular Weight: 26,242 Da
• NCBI Official Full Name: VPS24
• UniProt Protein Name: Vacuolar protein-sorting-associated protein 24
• Protein Family: Vacuolar protein sorting-associated protein
• UniProt Gene Name: VPS24
• UniProt Synonym Gene Names: DID3
• UniProt Entry Name: VPS24_YEAST

Uniprot Description

Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment oflate-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. The DID4/VPS2-VPS24 subcomplex is required for the VPS4-dependent dissociation of ESCRT-III.