Rabbit anti-Human VEGI Polyclonal Antibody | anti-VEGI antibody

Anti-VEGI Antibody

Cat. Num. AAA418214

• Gene Names: TNFSF15; TL1; TL1A; VEGI; TNLG1B; VEGI192A
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Purified by protein A affinity chromatography.
• Synonyms: VEGI; Polyclonal Antibody; Anti-VEGI Antibody; anti-VEGI antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by protein A affinity chromatography.
• Form/Format: Liquid
• Concentration: 1ug/ul (varies by lot)
• Sequence Length: 174

• Applicable Applications for anti-VEGI antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Immunogen: Ni-NTA purified truncated recombinant VEGI expressed in E Coli strain BL21 (DE3)
• Storage Buffer: PBS, pH 7.4 with 0.05% sodium azide.
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Western Blot (WB)

Related Product Information for anti-VEGI antibody

VEGI is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined

References

1. kang YJ et.al Cytokine. 2005 Mar 7;29 (5):229-35 2. Prehn JL et.al Clin Immunol. 2004 Jul;112 (1):66-77.

NCBI and Uniprot Product Information

• NCBI GI #: 4038081
• NCBI GeneID: 9966
• Molecular Weight: 20,131 Da
• NCBI Official Full Name: vascular endothelial cell growth inhibitor
• NCBI Official Synonym Full Names: tumor necrosis factor superfamily member 15
• NCBI Official Symbol: TNFSF15
• NCBI Official Synonym Symbols: TL1; TL1A; VEGI; TNLG1B; VEGI192A
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 15
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 15
• UniProt Gene Name: TNFSF15
• UniProt Synonym Gene Names: TL1; VEGI

NCBI Description

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Uniprot Description

TNFSF15: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q32

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: receptor binding

Biological Process: activation of NF-kappaB-inducing kinase; caspase activation; cytokine metabolic process; tumor necrosis factor-mediated signaling pathway