Goat VEGFR2 Polyclonal Antibody | anti-KDR antibody

Anti-VEGFR2

Cat. Num. AAA448083

• Gene Names: KDR; FLK1; CD309; VEGFR; VEGFR2
• Reactivity: Human, canine and mouse proteins.
• Applications: Western Blot
• Purity: Epitope Affinity Purified
• Synonyms: VEGFR2; Polyclonal Antibody; Anti-VEGFR2; CD309; Fetal liver kinase 1; FLK1; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1; VEGFR; VEGF receptor 2; Vascular endothelial growth factor receptor 2 antibody; anti-KDR antibody

• Host: Goat
• Reactivity: Human, canine and mouse proteins.
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This antibody reacts with a 180 kDa protein and detects endogenous levels of total VEGFR2 protein.
• Purity/Purification: Epitope Affinity Purified
• Form/Format: Polyclonal antibody supplied as a 200 ul (3 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum.
• Sequence Length: 1356

• Applicable Applications for anti-KDR antibody: Western Blot (WB)
• Application Notes: Western Blot: 1:250-1:2,000; Immunofluorescence: 1:25-1:250
• Immunogen: Recombinant peptide derived from the N-terminus (residues 20-125 aa) of human VEGFR2 produced in E.coli)
• Handling: The antibody solution should be gently mixed before use.
• Conjugation: Unconjugated
• Antigen: Purified recombinant peptide derived from the N-terminus (residues 20-125 aa) of human VEGFR2 produced in E. coli.
• Preparation and Storage: Store at -20°C for long-term storage.; Store at 2-8°C for up to one month.; Avoid freeze/thaw cycles.

Testing Data

Related Product Information for anti-KDR antibody

Goat polyclonal to VEGFR2. VEGFR2 known as kinase insert domain receptor, is a type III receptor tyrosine kinase. This VEGF receptor has a key function in vascular development and regulation of vascular permeability.

NCBI and Uniprot Product Information

• NCBI GI #: 11321597
• NCBI GeneID: 3791
• NCBI Accession #: NP_002244.1
• NCBI GenBank Nucleotide #: NM_002253.2
• NCBI Official Full Name: vascular endothelial growth factor receptor 2
• NCBI Official Synonym Full Names: kinase insert domain receptor
• NCBI Official Symbol: KDR
• NCBI Official Synonym Symbols: FLK1; CD309; VEGFR; VEGFR2
• NCBI Protein Information: vascular endothelial growth factor receptor 2; fetal liver kinase 1; fetal liver kinase-1; kinase insert domain receptor (a type III receptor tyrosine kinase); protein-tyrosine kinase receptor Flk-1; soluble VEGFR2; tyrosine kinase growth factor receptor
• UniProt Protein Name: Vascular endothelial growth factor receptor 2
• Protein Family: Vascular endothelial growth factor receptor
• UniProt Gene Name: KDR
• UniProt Synonym Gene Names: FLK1; VEGFR2; VEGFR-2; FLK-1; KDR
• UniProt Entry Name: VGFR2_HUMAN

NCBI Description

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

Uniprot Description

VEGFR2: a receptor tyrosine kinase of the VEGFR family. High affinity receptor for VEGF and VEGF-C. Ligand binding induces autophosphorylation and activation. Activated receptor recruits proteins including Shc, GRB2, PI3K, Nck, SHP-1 and SHP-2. Plays a key role in vascular development and regulation of vascular permeability.

Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Kinase, protein; Protein kinase, TK; TK group; VEGFR family

Chromosomal Location of Human Ortholog: 4q11-q12

Cellular Component: Golgi apparatus; endoplasmic reticulum; integral to plasma membrane; cytoplasmic membrane-bound vesicle; early endosome; extracellular region; plasma membrane; nucleus; cell junction; endosome; lipid raft; external side of plasma membrane

Molecular Function: integrin binding; vascular endothelial growth factor receptor activity; protein binding; growth factor binding; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; Hsp90 protein binding; ATP binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of positive chemotaxis; peptidyl-tyrosine phosphorylation; viral reproduction; protein amino acid autophosphorylation; cell maturation; calcium ion homeostasis; regulation of cell shape; positive regulation of MAPKKK cascade; ovarian follicle development; positive regulation of focal adhesion formation; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; angiogenesis; vasculogenesis; endothelial cell differentiation; cell fate commitment; embryonic hemopoiesis; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of angiogenesis; cell migration during sprouting angiogenesis; branching morphogenesis of a tube; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; lymph vessel development; vascular endothelial growth factor receptor signaling pathway; surfactant homeostasis; alveolus development; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; positive regulation of nitric-oxide synthase biosynthetic process; negative regulation of apoptosis

Disease: Hemangioma, Capillary Infantile