Immunohistochemistry (IHC)
(Human Heart (formalin-fixed, paraffin-embedded) stained with VDAC2 antibody at 2.5-5ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.)
Goat anti-Human VDAC2 Polyclonal Antibody | anti-VDAC2 antibody
VDAC2, CT (Voltage-dependent Anion-selective Channel Protein 2, VDAC-2, hVDAC2, Outer Mitochondrial Membrane Protein Porin 2)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: ELISA: 1:64,000
Western Blot: 1:64,000 & 0.3-1ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 2.5-5ug/ml
Immunohistochemistry (IHC)
(Human Heart (formalin-fixed, paraffin-embedded) stained with VDAC2 antibody at 2.5-5ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.)
Immunohistochemistry (IHC)
(Human Heart (formalin-fixed, paraffin-embedded) stained with VDAC2 antibody at 2.5-5ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.)
Chemiluminescence
(Antibody (0.3ug/ml) staining of Human Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Chemiluminescence
(Antibody (0.3ug/ml) staining of Human Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Description
VDAC2: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective. Interacts with hexokinases. Expressed in all tissues examined. Belongs to the eukaryotic mitochondrial porin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; Channel, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 10q22
Cellular Component: pore complex; mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; nucleus
Molecular Function: protein binding; nucleotide binding; voltage-gated anion channel activity; porin activity
Biological Process: negative regulation of protein polymerization; transmembrane transport; anion transport
Research Articles on VDAC2
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Product Notes
The VDAC2 vdac2 (Catalog #AAA6010559) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The VDAC2, CT (Voltage-dependent Anion-selective Channel Protein 2, VDAC-2, hVDAC2, Outer Mitochondrial Membrane Protein Porin 2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's VDAC2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in ELISA, Western Blot and Immunohistochemistry. Dilution: ELISA: 1:64,000 Western Blot: 1:64,000 & 0.3-1ug/ml Immunohistochemistry (Formalin fixed paraffin embedded): 2.5-5ug/ml. Researchers should empirically determine the suitability of the VDAC2 vdac2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VDAC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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