Testing Data
(Peptide Competition and Stimulation: Extracts prepared from PAE cells transfected with a chimeric receptor or from NIH3T3 cells transfected with human VEGFR2 were stimulated with VEGF (1-4, 6) or left unstimulated (5). Extracts were incubated with 0.50ug)
Rabbit anti-Mouse Vascular Endothelial Growth Factor Receptor 2 Polyclonal Antibody | anti-KDR antibody
Vascular Endothelial Growth Factor Receptor 2, phosphorylated (Tyr1054) (VEGF R2, Flk1, KDR, Receptor Tyrosine Kinase)
Purified by immunoaffinity chromatography
Purified by immunoaffinity chromatography
Dilution: Western Blot: 0.35-1ug/ml
Testing Data
(Peptide Competition and Stimulation: Extracts prepared from PAE cells transfected with a chimeric receptor or from NIH3T3 cells transfected with human VEGFR2 were stimulated with VEGF (1-4, 6) or left unstimulated (5). Extracts were incubated with 0.50ug)
Testing Data
(Peptide Competition and Stimulation: Extracts prepared from PAE cells transfected with a chimeric receptor or from NIH3T3 cells transfected with human VEGFR2 were stimulated with VEGF (1-4, 6) or left unstimulated (5). Extracts were incubated with 0.50ug)
Testing Data
(Peptide Competition and Stimulation Extracts prepared from PAE cells transfected with a chimeric receptor and stimulated with CSF (1-4) or from NIH3T3 cells transfected with human VEGFR2 left unstimulated (5) or stimulated with VEGF (6) were resolved by SDS-PAGE on a 10% polyacrylamide gel and transferred to PVDF. Membranes were blocked with a 5% BSA-TBST buffer overnight at 4C, then were incubated with 0.5ug/ml MBS630459 for two hours at RT in a 3% BSA-TBST buffer, following prior)
Testing Data
(Peptide Competition and Stimulation Extracts prepared from PAE cells transfected with a chimeric receptor and stimulated with CSF (1-4) or from NIH3T3 cells transfected with human VEGFR2 left unstimulated (5) or stimulated with VEGF (6) were resolved by SDS-PAGE on a 10% polyacrylamide gel and transferred to PVDF. Membranes were blocked with a 5% BSA-TBST buffer overnight at 4C, then were incubated with 0.5ug/ml MBS630459 for two hours at RT in a 3% BSA-TBST buffer, following prior)
NCBI and Uniprot Product Information
NCBI Description
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq]
Uniprot Description
VEGFR2: a receptor tyrosine kinase of the VEGFR family. High affinity receptor for VEGF and VEGF-C. Ligand binding induces autophosphorylation and activation. Activated receptor recruits proteins including Shc, GRB2, PI3K, Nck, SHP-1 and SHP-2. Plays a key role in vascular development and regulation of vascular permeability.
Protein type: Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; TK group; VEGFR family
Chromosomal Location of Human Ortholog: 4q11-q12
Cellular Component: Golgi apparatus; endoplasmic reticulum; integral to plasma membrane; cytoplasmic membrane-bound vesicle; early endosome; extracellular region; plasma membrane; nucleus; cell junction; endosome; external side of plasma membrane; lipid raft
Molecular Function: integrin binding; vascular endothelial growth factor receptor activity; protein binding; protein-tyrosine kinase activity; growth factor binding; Hsp90 protein binding; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: extracellular matrix organization and biogenesis; positive regulation of positive chemotaxis; peptidyl-tyrosine phosphorylation; viral reproduction; protein amino acid autophosphorylation; cell maturation; calcium ion homeostasis; regulation of cell shape; positive regulation of MAPKKK cascade; ovarian follicle development; positive regulation of focal adhesion formation; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; angiogenesis; vasculogenesis; endothelial cell differentiation; cell fate commitment; embryonic hemopoiesis; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of angiogenesis; branching morphogenesis of a tube; cell migration during sprouting angiogenesis; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; lymph vessel development; vascular endothelial growth factor receptor signaling pathway; surfactant homeostasis; alveolus development; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of cell migration
Disease: Hemangioma, Capillary Infantile
Research Articles on KDR
Similar Products
Product Notes
The KDR kdr (Catalog #AAA630459) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Vascular Endothelial Growth Factor Receptor 2, phosphorylated (Tyr1054) (VEGF R2, Flk1, KDR, Receptor Tyrosine Kinase) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Vascular Endothelial Growth Factor Receptor 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot: 0.35-1ug/ml. Researchers should empirically determine the suitability of the KDR kdr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Vascular Endothelial Growth Factor Receptor 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
