Rabbit anti-Human Vascular Endothelial Growth Factor D Polyclonal Antibody | anti-VEGFD antibody

Vascular Endothelial Growth Factor D, CT (FIGF, VEGFD, VEGF4, Vascular endothelial growth factor D, c-Fos-induced growth factor) (Biotin)

Cat. Num. AAA6362281

• Gene Names: FIGF; VEGFD; VEGF-D
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Purified by Protein G Affinity Chromatography.
• Synonyms: Vascular Endothelial Growth Factor D; Polyclonal Antibody; CT (FIGF; VEGFD; VEGF4; Vascular endothelial growth factor D; c-Fos-induced growth factor) (Biotin); FIGF; c-Fos-induced growth factor; anti-VEGFD antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein G Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-VEGFD antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: IHC: 1:50-100; ELISA: 1:1,000; WB: 1:250-500; Applications are based on unconjugated antibody.
• Immunogen: VEGFD (VEGF4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325~354 amino acids from the C-terminal region of human VEGF4.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of anti-VEGF4 Antibody (C-term) Pab (AP6292b) in 293 cell line lysates. VEGF4 Antibody (C-term)(arrow) was detected using the purified Pab.)

Immunohistochemistry (IHC)

(VEGFD (VEGF4) Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded mouse heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of VEGFD (VEGF4) Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-VEGFD antibody

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C.

Product Categories/Family for anti-VEGFD antibody

Antibodies; Growth Factors; Cytokines

References

Orlandini, M., et al., J. Biol. Chem. 278(45):44650-44656 (2003). McColl, B.K., et al., J. Exp. Med. 198(6):863-868 (2003). Rissanen, T.T., et al., Circ. Res. 92(10):1098-1106 (2003). Nakamura, Y., et al., Clin. Cancer Res. 9(2):716-721 (2003). Yokoyama, Y., et al., Br. J. Cancer 88(2):237-244 (2003).

NCBI and Uniprot Product Information

• NCBI GI #: 4758378
• NCBI GeneID: 2277
• NCBI Accession #: NP_004460.1
• NCBI GenBank Nucleotide #: NM_004469.4
• UniProt Accession #: O43915; B2R7Z3
• Molecular Weight: 40,444 Da
• NCBI Official Full Name: vascular endothelial growth factor D preproprotein
• NCBI Official Synonym Full Names: c-fos induced growth factor (vascular endothelial growth factor D)
• NCBI Official Symbol: FIGF
• NCBI Official Synonym Symbols: VEGFD; VEGF-D
• NCBI Protein Information: vascular endothelial growth factor D
• UniProt Protein Name: Vascular endothelial growth factor D
• Protein Family: Vascular endothelial growth factor
• UniProt Gene Name: FIGF
• UniProt Synonym Gene Names: VEGFD; VEGF-D; FIGF
• UniProt Entry Name: VEGFD_HUMAN

NCBI Description

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]

Uniprot Description

VEGFD: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Belongs to the PDGF/VEGF growth factor family.

Protein type: Cytokine; Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: Xp22.31

Cellular Component: extracellular space; membrane; extracellular region

Molecular Function: protein homodimerization activity; growth factor activity; platelet-derived growth factor receptor binding; vascular endothelial growth factor receptor 3 binding; vascular endothelial growth factor receptor binding; chemoattractant activity

Biological Process: cell proliferation; platelet activation; platelet degranulation; positive chemotaxis; positive regulation of cell division; positive regulation of cell proliferation; angiogenesis; blood coagulation; vascular endothelial growth factor receptor signaling pathway; cell differentiation; induction of positive chemotaxis