Rabbit anti-Human VAMP1 Polyclonal Antibody | anti-VAMP1 antibody

VAMP1 Antibody

Cat. Num. AAA9403673

• Gene Names: VAMP1; SYB1; SPAX1; VAMP-1
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: VAMP1; Polyclonal Antibody; VAMP1 Antibody; SYB1; SPAX1; VAMP-1; anti-VAMP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total VAMP1 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 1.5 mg/ml (varies by lot)
• Sequence Length: 116

• Applicable Applications for anti-VAMP1 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:20-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide of human vesicle-associated membrane protein 1 (synaptobrevin 1)
• Target Name: VAMP1
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/25.)

Related Product Information for anti-VAMP1 antibody

Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined.

Product Categories/Family for anti-VAMP1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 662033932
• NCBI GeneID: 6843
• NCBI Accession #: NP_001284367.1
• NCBI GenBank Nucleotide #: NM_001297438.1
• UniProt Accession #: P23763; O75468; Q15857; Q6FG94; Q8IVC9; A8MVP3; D3DUR3
• Molecular Weight: 12,658 Da
• NCBI Official Full Name: vesicle-associated membrane protein 1 isoform 4
• NCBI Official Synonym Full Names: vesicle-associated membrane protein 1 (synaptobrevin 1)
• NCBI Official Symbol: VAMP1
• NCBI Official Synonym Symbols: SYB1; SPAX1; VAMP-1
• NCBI Protein Information: vesicle-associated membrane protein 1
• UniProt Protein Name: Vesicle-associated membrane protein 1
• Protein Family: Vesicle-associated membrane protein
• UniProt Gene Name: VAMP1
• UniProt Synonym Gene Names: SYB1; VAMP-1
• UniProt Entry Name: VAMP1_HUMAN

NCBI Description

Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]

Uniprot Description

VAMP1: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p

Cellular Component: SNARE complex; mitochondrial outer membrane; synaptic vesicle; neuron projection; cell surface; synaptic vesicle membrane; integral to plasma membrane; cell junction; cytosol

Molecular Function: SNAP receptor activity; SNARE binding; protein binding

Biological Process: vesicle fusion; exocytosis; pathogenesis

Disease: Spastic Ataxia 1, Autosomal Dominant