Western Blot (WB)
(WB Suggested Anti-VAC14 antibody Titration: 1 ug/mLSample Type: Human 293T Whole Cell)
Rabbit anti-Human VAC14 Polyclonal Antibody | anti-VAC14 antibody
VAC14 Antibody - C-terminal region
Western Blot (WB)
(WB Suggested Anti-VAC14 antibody Titration: 1 ug/mLSample Type: Human 293T Whole Cell)
Western Blot (WB)
(WB Suggested Anti-VAC14 antibody Titration: 1 ug/mLSample Type: Human 293T Whole Cell)
Target Description: The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a scaffold protein that is a component of the PIKfyve protein kinase complex. This complex is responsible for the synthesis of phosphatidylinositol 3,5-bisphosphate, an important component of cellular membranes, from phosphatidylinositol 3-phosphate. Mice lacking a functional copy of this gene exhibit severe neurodegeneration. Mutations in the human gene have been identified in patients with a childhood onset progressive neurological disorder characterized by impaired movement, dystonia, and striatal abnormalities. [provided by RefSeq, May 2017]
Uniprot Description
VAC14: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. Belongs to the VAC14 family.
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: Golgi membrane; endoplasmic reticulum; late endosome membrane; early endosome membrane; endosome membrane
Molecular Function: protein binding; receptor activity
Biological Process: viral reproduction; phospholipid metabolic process; phosphatidylinositol biosynthetic process; regulation of lipid kinase activity; signal transduction
Research Articles on VAC14
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Product Notes
The VAC14 vac14 (Catalog #AAA3219626) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The VAC14 Antibody - C-terminal region reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's VAC14 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the VAC14 vac14 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: LKDLEVLAEI ASSPAGQTDD PGPLDGPDLQ ASHSELQVPT PGRAGLLNTS. It is sometimes possible for the material contained within the vial of "VAC14, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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