Rabbit v-ral simian leukemia viral oncogene homolog B Polyclonal Antibody | anti-RALB antibody

Rabbit anti-human v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) polyclonal Antibody

Cat. Num. AAA712220

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Antigen Affinity Purified
• Synonyms: v-ral simian leukemia viral oncogene homolog B; Polyclonal Antibody; Rabbit anti-human v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) polyclonal Antibody; v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein);; anti-RALB antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Sequence Length: 227

• Applicable Applications for anti-RALB antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Human RALB
• Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1531

NCBI and Uniprot Product Information

• NCBI GI #: 119615648
• NCBI GeneID: 5899
• Molecular Weight: 25,710 Da
• NCBI Official Full Name: v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein), isoform CRA_b
• NCBI Official Synonym Full Names: v-ral simian leukemia viral oncogene homolog B
• NCBI Official Symbol: RALB
• NCBI Protein Information: ras-related protein Ral-B; RAS-like protein B; ras related GTP binding protein B; v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)
• UniProt Protein Name: Ras-related protein Ral-B
• Protein Family: Ras-related protein
• UniProt Gene Name: RALB
• UniProt Entry Name: RALB_HUMAN

NCBI Description

This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]

Uniprot Description

RALB: Multifuntional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis. Interacts with EXOC2 and EXOC8. Interacts with RALBP1 via its effector domain. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family.

Protein type: G protein, monomeric, Ras; G protein; G protein, monomeric

Chromosomal Location of Human Ortholog: 2q14.2

Cellular Component: plasma membrane; exocyst; autophagic vacuole; midbody

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; ubiquitin protein ligase binding; ATPase binding

Biological Process: regulation of exocyst localization; positive regulation of protein binding; nerve growth factor receptor signaling pathway; apoptosis; metabolic process; regulation of exocyst assembly; Ras protein signal transduction; cytokinesis; positive regulation of protein amino acid phosphorylation; cellular response to starvation; signal transduction; negative regulation of protein binding