Western Blot (WB)
(Western blot analysis of UVRAG in human heart lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse heart and 4) rat heart using at 1ug/ml, 0.5ug/ml and 0.5ug/ml, respectively.)
Rabbit UVRAG Polyclonal Antibody | anti-UVRAG antibody
UVRAG (UV Radiation Resistance-associated Gene Protein, p63, DHTX, VPS38)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: Western Blot: 0.5-1ug/ml
Western Blot (WB)
(Western blot analysis of UVRAG in human heart lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse heart and 4) rat heart using at 1ug/ml, 0.5ug/ml and 0.5ug/ml, respectively.)
Western Blot (WB)
(Western blot analysis of UVRAG in human heart lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse heart and 4) rat heart using at 1ug/ml, 0.5ug/ml and 0.5ug/ml, respectively.)
NCBI and Uniprot Product Information
NCBI Description
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Uniprot Description
Subunit structure: Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes with BECN1 through direct competition. Directly interacts with FEZ1 and SCOC. The interaction with SCOC is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1. Interacts with BECN1P1/BECN2. Ref.3 Ref.6 Ref.8 Ref.11 Ref.12
Subcellular location: Late endosome. Lysosome. Early endosome. Note: Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial. Ref.3
Tissue specificity: Highly expressed in brain, lung, kidney and liver. Ref.2
Involvement in disease: A chromosomal aberration involving UVRAG has been observed in a patient with heterotaxy (left-right axis malformation). Inversion Inv11(q13.5;q25).
Sequence similarities: Contains 1 C2 domain.
Sequence caution: The sequence CAA67507.1 differs from that shown. Reason: Erroneous gene model prediction.
Research Articles on UVRAG
Similar Products
Product Notes
The UVRAG uvrag (Catalog #AAA646224) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The UVRAG (UV Radiation Resistance-associated Gene Protein, p63, DHTX, VPS38) reacts with Canine, Chicken, Human, Monkey, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's UVRAG can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot: 0.5-1ug/ml. Researchers should empirically determine the suitability of the UVRAG uvrag for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "UVRAG, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
