Rabbit anti-Human UVRAG Polyclonal Antibody | anti-UVRAG antibody

UVRAG Antibody, Biotin conjugated

Cat. Num. AAA7046224

• Gene Names: UVRAG; p63; DHTX; VPS38
• Reactivity: Human
• Applications: ELISA
• Purity: >95%, Protein G purified
• Synonyms: UVRAG; Polyclonal Antibody; UVRAG Antibody; Biotin conjugated; UV radiation resistance-associated gene protein; p63; anti-UVRAG antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 699

• Applicable Applications for anti-UVRAG antibody: ELISA (EIA)
• Species: Human
• Immunogen: Recombinant human UV radiation resistance-associated gene protein
• Conjugate: Biotin
• Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-82115 / sc-82116 / sc-292327
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-UVRAG antibody

Versatile protein that is involved in regulation of differenent cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300).

NCBI and Uniprot Product Information

• NCBI GI #: 21687212
• NCBI GeneID: 7405
• NCBI Accession #: NP_003360.2
• NCBI GenBank Nucleotide #: NM_003369.3
• UniProt Accession #: Q9P2Y5; O00392; B3KTC1
• Molecular Weight: 35,988 Da
• NCBI Official Full Name: UV radiation resistance-associated gene protein
• NCBI Official Synonym Full Names: UV radiation resistance associated
• NCBI Official Symbol: UVRAG
• NCBI Official Synonym Symbols: p63; DHTX; VPS38
• NCBI Protein Information: UV radiation resistance-associated gene protein
• UniProt Protein Name: UV radiation resistance-associated gene protein
• Protein Family: UV radiation resistance associated protein
• UniProt Gene Name: UVRAG
• UniProt Entry Name: UVRAG_HUMAN

NCBI Description

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]

Uniprot Description

UVRAG: Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes with BECN1 through direct competition. Highly expressed in brain, lung, kidney and liver.

Protein type: Autophagy

Chromosomal Location of Human Ortholog: 11q13.5

Cellular Component: centrosome; cytoplasm; early endosome; endoplasmic reticulum; late endosome; lysosome; midbody

Molecular Function: protein binding; SNARE binding

Biological Process: autophagy; centrosome organization and biogenesis; DNA repair; maintenance of Golgi localization; receptor catabolic process; regulation of cytokinesis; retrograde vesicle-mediated transport, Golgi to ER