Rabbit anti-Human UTX Polyclonal Antibody | anti-UTX antibody
UTX polyclonal antibody
Gene Names
KDM6A; UTX; KABUK2; bA386N14.2
Reactivity
Human
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Synonyms
UTX; Polyclonal Antibody; UTX polyclonal antibody; Lysine-specific demethylase 6A;HistonedemethylaseUTX;Ubiquitously-transcribed TPR protein on the X chromosome; Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein; KDM6A; anti-UTX antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
UTX polyclonal antibody detects endogenous levels of UTX protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Applicable Applications for anti-UTX antibody
Western Blot (WB)
Application Notes
WB: 1:1000~1:2000
Immunogen
Synthetic peptide, corresponding to Human UTX.
Preparation and Storage
Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Related Product Information for anti-UTX antibody
The methylation state of lysine residues in histone proteins is a major determinant of the formation of active and inactive regions of the genome and is crucial for proper programming of the genome during development. Jumonji C (JmjC) domain-containing proteins represent the largest class of potential histone demethylase proteins. The JmjC domain can catalyze the demethylation of mono-, di-, and tri-methyl lysine residues via an oxidative reaction that requires iron and alpha-ketoglutarate. Based on homology, both humans and mice contain at least 30 such proteins, which can be divided into 7 separate families. The three members of the UTX/UTY family include the ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX), the ubiquitously transcribed Y chromosome tetratricopeptide repeat protein (UTY) and JmjC domain-containing protein 3 (JMJD3). This family of proteins has been shown to demethylate both di- and tri-methyl histone H3 Lys 27. The UTX gene escapes X inactivation in females and is ubiquitously expressed. UTX functions to regulate HOX gene expression during development. JMJD3 functions to regulate gene expression in macrophages responding to various inflammatory stimuli and has been shown to be upregulated in prostate cancer. Both UTX and JMJD3 interact with mixed-lineage leukemia (MLL) complexes 2 and 3, both of which have been shown to methylate histone H3 at Lys4. The UTY gene is expressed in most tissues in the male mouse.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
154,177 Da
NCBI Official Full Name
lysine-specific demethylase 6A isoform 3
NCBI Official Synonym Full Names
lysine (K)-specific demethylase 6A
NCBI Official Symbol
KDM6A
NCBI Official Synonym Symbols
UTX; KABUK2; bA386N14.2
NCBI Protein Information
lysine-specific demethylase 6A; bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)); histone demethylase UTX; ubiquitously transcribed tetratricopeptide repeat protein X-linked; ubiquitously-transcribed TPR gene on th
UniProt Protein Name
Lysine-specific demethylase 6A
UniProt Gene Name
KDM6A
UniProt Synonym Gene Names
UTX
UniProt Entry Name
KDM6A_HUMAN
Similar Products
Product Notes
The UTX kdm6a (Catalog #AAA3015855) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The UTX polyclonal antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's UTX can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:1000~1:2000. Researchers should empirically determine the suitability of the UTX kdm6a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "UTX, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
