Western Blot (WB)
(Western blot analysis of Rat Inner medulla showing detection of UT-A1 protein using Rabbit Anti-UT-A1 Polyclonal Antibody (SPC-406). Primary Antibody: Rabbit Anti-UT-A1 Polyclonal Antibody (SPC-406) at 1:1000.)
Rabbit anti-Rat, Mouse UT-A1 Polyclonal Antibody | anti-Slc14a2 antibody
UT-A1 Antibody: Biotin
Gene Names
Slc14a2; UrT1-C; UrT1-D; Slc14a2T; Slc14a2_v4; testSymbol
Reactivity
Rat, Mouse
Applications
Western Blot, Immunocytochemistry
Synonyms
UT-A1; Polyclonal Antibody; UT-A1 Antibody: Biotin; Slc14a2; anti-Slc14a2 antibody
Host
Rabbit
Reactivity
Rat, Mouse
Clonality
Polyclonal
Form/Format
Affinity Purified
Concentration
1mg/mL (varies by lot)
Sequence Length
929
Applicable Applications for anti-Slc14a2 antibody
Western Blot (WB), Immunocytochemistry (ICC)
Application Notes
1:1000 (WB)
Conjugate
Biotin
Storage Buffer
PBS, 50% glycerol, 0.09% sodium azide.
Preparation and Storage
-20 degree C
Western Blot (WB)
(Western blot analysis of Rat Inner medulla showing detection of UT-A1 protein using Rabbit Anti-UT-A1 Polyclonal Antibody (SPC-406). Primary Antibody: Rabbit Anti-UT-A1 Polyclonal Antibody (SPC-406) at 1:1000.)
Western Blot (WB)
(Western blot analysis of Rat Inner medulla showing detection of UT-A1 protein using Rabbit Anti-UT-A1 Polyclonal Antibody (SPC-406). Primary Antibody: Rabbit Anti-UT-A1 Polyclonal Antibody (SPC-406) at 1:1000.)
Related Product Information for anti-Slc14a2 antibody
Background Info: Detects ~97 and 117kDa.
Scientific Background: UT-A1, a kidney-specific urea transporter is expressed in the renal collecting duct where it mediates trans-epithelial urea transport and is a target for regulation by vasopressin. Urea movement out of the collecting duct in the inner medulla of the kidney allows accumulation of urea in the medullary interstitium, thereby allowing maximum water reabsorption from the collecting ducts. (The antibody also recognizes a second protein from the UT-A gene driven by transcription from an alternative promoter and expressed in the thin descending limb of Henle, viz. UT-A2.) (1, 2)
Scientific Background: UT-A1, a kidney-specific urea transporter is expressed in the renal collecting duct where it mediates trans-epithelial urea transport and is a target for regulation by vasopressin. Urea movement out of the collecting duct in the inner medulla of the kidney allows accumulation of urea in the medullary interstitium, thereby allowing maximum water reabsorption from the collecting ducts. (The antibody also recognizes a second protein from the UT-A gene driven by transcription from an alternative promoter and expressed in the thin descending limb of Henle, viz. UT-A2.) (1, 2)
Product Categories/Family for anti-Slc14a2 antibody
References
1. Nielsen S, Terris J, Smith CP, Hediger MA, Ecelbarger CA, Knepper MA. (1996) Proc Natl Acad Sci U S A. 93(11): 5495-500. 2. Smith C.P. (2009) Exp Physiol. 94(2): 180-185.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
51,258 Da
NCBI Official Full Name
urea transporter 2 isoform 1
NCBI Official Synonym Full Names
solute carrier family 14 (urea transporter), member 2
NCBI Official Symbol
Slc14a2
NCBI Official Synonym Symbols
UrT1-C; UrT1-D; Slc14a2T; Slc14a2_v4; testSymbol
NCBI Protein Information
urea transporter 2; testName; urea transport protein; urea transporter, kidney; plasma membrane urea transporter; solute carrier family 14, member 2; solute carrier family 14 (urea transporter), member 2T; solute carrier family 14 (urea transporter), member 2, variant 4
UniProt Protein Name
Urea transporter 2
Protein Family
UniProt Gene Name
Slc14a2
UniProt Synonym Gene Names
Ut2
UniProt Entry Name
UT2_RAT
NCBI Description
acts as an cAMP inducible urea transporter; may play a role in vasopressin regulated renal water absorption [RGD, Feb 2006]
Uniprot Description
SLC14A2: Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. Belongs to the urea transporter family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: apical plasma membrane; integral to membrane
Molecular Function: protein binding; urea transmembrane transporter activity; cell adhesion molecule binding
Biological Process: urea transport; response to water deprivation
Research Articles on Slc14a2
Similar Products
Product Notes
The Slc14a2 slc14a2 (Catalog #AAA805499) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The UT-A1 Antibody: Biotin reacts with Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's UT-A1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC). 1:1000 (WB). Researchers should empirically determine the suitability of the Slc14a2 slc14a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "UT-A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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