Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human prostate cancer slide using MBS7605558 (USP33 Antibody) at dilution of 1:50)
Rabbit USP33 Polyclonal Antibody | anti-USP33 antibody
USP33 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human prostate cancer slide using MBS7605558 (USP33 Antibody) at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human prostate cancer slide using MBS7605558 (USP33 Antibody) at dilution of 1:50)
Western Blot (WB)
(HEK-293 cells were subjected to SDS PAGE followed by western blot with MBS7605558 (USP33 antibody) at dilution of 1:300)
Western Blot (WB)
(HEK-293 cells were subjected to SDS PAGE followed by western blot with MBS7605558 (USP33 antibody) at dilution of 1:300)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Uniprot Description
USP33: Deubiquitinating enzyme involved in various processes such as cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta- arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the peptidase C19 family. USP20/USP33 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin-specific protease; EC 3.4.19.12; Ubiquitin conjugating system; Protease
Chromosomal Location of Human Ortholog: 1p31.1
Cellular Component: autophagic vacuole; centrosome; cytoplasm; focal adhesion; Golgi apparatus; nucleoplasm; perinuclear region of cytoplasm; VCB complex
Molecular Function: cysteine-type endopeptidase activity; G-protein-coupled receptor binding; protein binding; Ral GTPase binding; ubiquitin binding; ubiquitin-specific protease activity; zinc ion binding
Biological Process: axon guidance; cell migration; cellular response to starvation; centrosome duplication; endocytosis; negative regulation of protein binding; positive regulation of protein binding; protein deubiquitination; protein stabilization; regulation of autophagy; regulation of G-protein coupled receptor protein signaling pathway; ubiquitin-dependent protein catabolic process
Research Articles on USP33
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Product Notes
The USP33 usp33 (Catalog #AAA7605558) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The USP33 Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's USP33 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the USP33 usp33 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "USP33, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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