Rabbit anti-Human, Mouse USP10 Polyclonal Antibody | anti-USP10 antibody

Rabbit Polyclonal to Human USP10

Cat. Num. AAA247674

• Gene Names: USP10; UBPO
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Immunocytochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: USP10; Polyclonal Antibody; Rabbit Polyclonal to Human USP10; Anti-USP10 Antibody (N-Terminus) IHC-plus; KIAA0190; Ubiquitin thiolesterase 10; UBPO; Ubiquitin specific protease 10; Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Human USP10; anti-USP10 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: Human USP10
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 802

• Applicable Applications for anti-USP10 antibody: Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA, ICC, IHC-P (5 ug/ml), WB (1 - 2 ug/ml); Usage: USP10 antibody can be used for detection of USP10 by Western blot at 1-2 ug/ml.
• Target Species: Human
• Immunogen Description: A 16 amino acid peptide near the amino terminus of human USP10.
• Immunogen Type: Synthetic peptide
• Immunogen: USP10 antibody was raised against a 16 amino acid peptide near the amino terminus of human USP10.
• Antigen Modification: N-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-USP10 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-USP10 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-USP10 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of USP10 in Jurkat cells with USP10 antibody at 20 ug/ml.)

Immunocytochemistry (ICC)

(Immunocytochemistry of USP10 in Jurkat cells with USP10 antibody at 20 ug/ml.)

Western Blot (WB)

(Western blot analysis of USP10 in Jurkat cell lysate with USP10 antibody at (A) 1 and (B) 2 ug/ml.)

Product Categories/Family for anti-USP10 antibody

Family: Protease; Subfamily: Cysteine C19

NCBI and Uniprot Product Information

• NCBI GI #: 440918695
• NCBI GeneID: 9100
• NCBI Accession #: NP_001259004.1
• NCBI GenBank Nucleotide #: NM_001272075.1
• UniProt Accession #: Q14694; Q9BWG7; Q9NSL7; B2RDJ8; B4DS84
• Molecular Weight: 87,533 Da
• NCBI Official Full Name: ubiquitin carboxyl-terminal hydrolase 10 isoform 1
• NCBI Official Synonym Full Names: ubiquitin specific peptidase 10
• NCBI Official Symbol: USP10
• NCBI Official Synonym Symbols: UBPO
• NCBI Protein Information: ubiquitin carboxyl-terminal hydrolase 10; ubiquitin thioesterase 10; deubiquitinating enzyme 10; ubiquitin thiolesterase 10; ubiquitin specific protease 10; ubiquitin-specific-processing protease 10
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase 10
• UniProt Gene Name: USP10
• UniProt Synonym Gene Names: KIAA0190
• UniProt Entry Name: UBP10_HUMAN

NCBI Description

Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]

Uniprot Description

USP10: a carboxyl-terminal ubiquitin-processing protease. Ras-GAP SH3 domain-binding protein (G3BP) appears to inhibit its ability to disassemble ubiquitin chains.

Protein type: EC 3.4.19.12; Ubiquitin conjugating system; RNA-binding; Protease; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: early endosome; cytoplasm; nucleus

Molecular Function: protein binding; p53 binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; DNA damage response, signal transduction by p53 class mediator; autophagy; regulation of autophagy; DNA repair