Rabbit anti-Human, Mouse USP10 Polyclonal Antibody | anti-USP10 antibody

USP10 Antibody

Cat. Num. AAA9404939

• Gene Names: USP10; UBPO
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunocytochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: USP10; Polyclonal Antibody; USP10 Antibody; Ubiquitin specific peptidase 10; ubiquitin carboxyl-terminal hydrolase 10; UBPO; de-ubiquitinating enzyme 10; anti-USP10 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 798

• Applicable Applications for anti-USP10 antibody: ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 16 amino acid peptide near the amino terminus of human USP10.
• Target Name: USP10
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of USP10 in Jurkat cell lysate with USP10 antibody at (A) 1 and (B) 2 ug/mL.)

Immunocytochemistry (ICC)

(Immunocytochemistry of USP10 in Jurkat cells with USP10 antibody at 20 ug/mL.)

Related Product Information for anti-USP10 antibody

USP10, also known as ubiquitin specific peptidase 10, belongs to the ubiquitin-specific protease family of cysteine proteases. USP10 functions to catalyze the cleavage of ubiquitin from ubiquitin-conjugated protein substrates such as p53/TP53, SNX3 and CFTR. USP10 has been identified as a subunit of DNA-bound androgen receptor (AR) complexes and may play a role in the activity of the DNA-bound androgen receptor complex. USP10 also acts as an essential regulator of p53/TP53 stability and is thought to function as a tumor suppressor.

Product Categories/Family for anti-USP10 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 119220605
• NCBI GeneID: 9100
• NCBI Accession #: NP_005144
• NCBI GenBank Nucleotide #: NM_005153.2
• Molecular Weight: 87,533 Da
• NCBI Official Full Name: ubiquitin carboxyl-terminal hydrolase 10 isoform 2
• NCBI Official Synonym Full Names: ubiquitin specific peptidase 10
• NCBI Official Symbol: USP10
• NCBI Official Synonym Symbols: UBPO
• NCBI Protein Information: ubiquitin carboxyl-terminal hydrolase 10
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase 10
• UniProt Gene Name: USP10
• UniProt Synonym Gene Names: KIAA0190
• UniProt Entry Name: UBP10_HUMAN

NCBI Description

Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]

Uniprot Description

USP10: a carboxyl-terminal ubiquitin-processing protease. Ras-GAP SH3 domain-binding protein (G3BP) appears to inhibit its ability to disassemble ubiquitin chains.

Protein type: Protease; Ubiquitin-specific protease; Ubiquitin conjugating system; RNA-binding; EC 3.4.19.12

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: cytoplasm; early endosome; nucleus

Molecular Function: protein binding; p53 binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; DNA damage response, signal transduction by p53 class mediator; autophagy; regulation of autophagy; DNA repair