Western Blot (WB)
(Western blot analysis of ULK2 in human brain tissue lysate with ULK2 antibody at 1 μg/mL.)
Rabbit anti-Human ULK2 Polyclonal Antibody | anti-ULK2 antibody
ULK2 Antibody
Western Blot (WB)
(Western blot analysis of ULK2 in human brain tissue lysate with ULK2 antibody at 1 μg/mL.)
Western Blot (WB)
(Western blot analysis of ULK2 in human brain tissue lysate with ULK2 antibody at 1 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of ULK2 in human brain tissue with ULK2 antibody at 2.5 μg/ml.)
Immunohistochemistry (IHC)
(Immunohistochemistry of ULK2 in human brain tissue with ULK2 antibody at 2.5 μg/ml.)
Immunofluorescence (IF)
(Immunofluorescence of ULK2 in human brain tissue with ULK2 antibody at 20 μg/ml.)
Immunofluorescence (IF)
(Immunofluorescence of ULK2 in human brain tissue with ULK2 antibody at 20 μg/ml.)
NCBI and Uniprot Product Information
Observed: 100 kDa
NCBI Description
This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]
Uniprot Description
ULK2: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Protein type: Kinase, protein; Autophagy; EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; ULK family
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: cytoplasmic vesicle membrane; pre-autophagosomal structure membrane; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: response to starvation; axon extension; protein amino acid autophosphorylation; regulation of autophagy; negative regulation of collateral sprouting; signal transduction; autophagic vacuole formation
Research Articles on ULK2
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Product Notes
The ULK2 ulk2 (Catalog #AAA153350) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ULK2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ULK2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). ULK2 Antibody can be used for detection of ULK2 by Western blot at 1 mug/mL. Researchers should empirically determine the suitability of the ULK2 ulk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ULK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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