Rabbit UGT1A9 Polyclonal Antibody | anti-UGT1A9 antibody

UGT1A9 Antibody

Cat. Num. AAA9402743

• Gene Names: UGT1A9; LUGP4; UDPGT; UGT1I; HLUGP4; UGT-1I; UGT1-9; UGT1.9; UGT1AI; UGT1-09; UGT1A9S; UDPGT 1-9
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: UGT1A9; Polyclonal Antibody; UGT1A9 Antibody; LUGP4; UDPGT; UGT1I; HLUGP4; UGT-1I; anti-UGT1A9 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total UGT1A9 protein.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 530

• Applicable Applications for anti-UGT1A9 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunohistochemistry: 1:50 - 1:100; Immunofluorescence: 1:50 - 1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human UGT1A9.
• Target Name: UGT1A9
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using UGT1A9 antibody.)

Immunofluorescence (IF)

(Immunofluorescence analysis of MCF7 cell using UGT1A9 antibody. Blue: DAPI for nuclear staining.)

Related Product Information for anti-UGT1A9 antibody

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols.

Product Categories/Family for anti-UGT1A9 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 11276085
• NCBI GeneID: 54600
• NCBI Accession #: NP_066307.1
• NCBI GenBank Nucleotide #: NM_021027.2
• UniProt Accession #: O60656; P36509; Q9HAX0; B8K285
• Molecular Weight: 49,718 Da
• NCBI Official Full Name: UDP-glucuronosyltransferase 1-9
• NCBI Official Synonym Full Names: UDP glucuronosyltransferase 1 family, polypeptide A9
• NCBI Official Symbol: UGT1A9
• NCBI Official Synonym Symbols: LUGP4; UDPGT; UGT1I; HLUGP4; UGT-1I; UGT1-9; UGT1.9; UGT1AI; UGT1-09; UGT1A9S; UDPGT 1-9
• NCBI Protein Information: UDP-glucuronosyltransferase 1-9
• UniProt Protein Name: UDP-glucuronosyltransferase 1-9
• Protein Family: UDP-glucuronosyltransferase
• UniProt Gene Name: UGT1A9
• UniProt Synonym Gene Names: GNT1; UGT1; UDPGT 1-9; UGT1*9; UGT1-09; UGT1.9; UGT-1I; UGT1I
• UniProt Entry Name: UD19_HUMAN

NCBI Description

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq, Jul 2008]

Uniprot Description

UGT1A9: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Endoplasmic reticulum; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Transferase; Carbohydrate Metabolism - pentose and glucuronate interconversions; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Carbohydrate Metabolism - starch and sucrose; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Carbohydrate Metabolism - ascorbate and aldarate; Cofactor and Vitamin Metabolism - retinol

Chromosomal Location of Human Ortholog: 2q37

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: enzyme inhibitor activity; retinoic acid binding; enzyme binding; protein homodimerization activity; protein heterodimerization activity; glucuronosyltransferase activity

Biological Process: negative regulation of transferase activity; flavonoid biosynthetic process; metabolic process; xenobiotic metabolic process; flavone metabolic process; retinoic acid metabolic process; negative regulation of fatty acid metabolic process; cellular lipid metabolic process; drug metabolic process; cellular response to hormone stimulus