Rabbit UCP3 Polyclonal Antibody | anti-UCP3 antibody

UCP3 Antibody

Cat. Num. AAA9509092

• Gene Names: UCP3; SLC25A9
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Synonyms: UCP3; Polyclonal Antibody; UCP3 Antibody; mitochondrial uncoupling protein 3; SLC25A9; UCP 3; uncoupling protein-3; Solute carrier family 25 member 9; anti-UCP3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: UCP3 antibody detects endogenous levels of UCP3.
• Purity/Purification: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 209

• Applicable Applications for anti-UCP3 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; ELISA: 1:10000
• Target Modification: Unmodified/Total
• Immunogen: The antiserum was produced against synthesized peptide derived from human UCP3.
• Immunogen Range: 259-308
• Preparation and Storage: Stable at -20 degree C for at least 1 year.

Western Blot (WB)

(Western blot analysis of lysate from Jurkat cells, using UCP3 antibody.)

NCBI and Uniprot Product Information

• NCBI GI #: 4507807
• NCBI GeneID: 7352
• NCBI Accession #: NP_003347.1
• NCBI GenBank Nucleotide #: NM_003356.3
• UniProt Accession #: P55916; O60475; Q96HL3
• Molecular Weight: 34 kDa
• NCBI Official Full Name: mitochondrial uncoupling protein 3 isoform UCP3L
• NCBI Official Synonym Full Names: uncoupling protein 3
• NCBI Official Symbol: UCP3
• NCBI Official Synonym Symbols: SLC25A9
• NCBI Protein Information: mitochondrial uncoupling protein 3
• UniProt Protein Name: Mitochondrial uncoupling protein 3
• Protein Family: UBA domain-containing protein
• UniProt Gene Name: UCP3
• UniProt Synonym Gene Names: SLC25A9; UCP 3

NCBI Description

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]

Uniprot Description

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.