Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using MBS7130101(UCP3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200))
Rabbit UCP3 Polyclonal Antibody | anti-UCP3 antibody
UCP3 Antibody
WB: 1:200-1:1000
IHC: 1:10-1:50
Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using MBS7130101(UCP3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200))
Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using MBS7130101(UCP3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200))
Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using MBS7130101(UCP3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200))
Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using MBS7130101(UCP3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200))
SDS-Page
(Gel: 8%SDS-PAGE,Lysate: 40 ug,,Primary antibody: MBS7130101(UCP3 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute)
SDS-Page
(Gel: 8%SDS-PAGE,Lysate: 40 ug,,Primary antibody: MBS7130101(UCP3 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute)
NCBI and Uniprot Product Information
NCBI Description
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]
Uniprot Description
UCP3: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance. Defects in UCP3 may be involved in obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Belongs to the mitochondrial carrier family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane
Molecular Function: protein binding; transporter activity; oxidative phosphorylation uncoupler activity
Biological Process: response to superoxide; response to glucocorticoid stimulus; respiratory gaseous exchange; fatty acid metabolic process; mitochondrial transport; cellular response to hormone stimulus; response to insulin stimulus; cellular metabolic process; proton transport; response to hypoxia; response to cold; lipid metabolic process; response to activity; response to nutrient; aging
Disease: Obesity
Research Articles on UCP3
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Product Notes
The UCP3 ucp3 (Catalog #AAA7130101) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The UCP3 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's UCP3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). ELISA: 1:1000-1:2000 WB: 1:200-1:1000 IHC: 1:10-1:50. Researchers should empirically determine the suitability of the UCP3 ucp3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "UCP3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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