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Western Blot (WB) (Host: RabbitTarget Name: TUFMSample Tissue: Mouse Pancreas lysatesAntibody Dilution: 1ug/ml)

Rabbit anti-Mouse TUFM Polyclonal Antibody | anti-TUFM antibody

TUFM Antibody-middle region

Reactivity
Mouse
Applications
Western Blot
Purity
Affinity Purified
Synonyms
TUFM; Polyclonal Antibody; TUFM Antibody-middle region; elongation factor Tu; mitochondrial; EFTU; C76308; C76389; EF-TuMT; 2300002G02Rik; anti-TUFM antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration
Batch dependent within range: 100ul at 0.5-1mg/ml (varies by lot)
Sequence
DHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEERARGITINAAHVEYS
Applicable Applications for anti-TUFM antibody
Western Blot (WB)
Protein Size
452 amino acids
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of mouse TUFM
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Host: RabbitTarget Name: TUFMSample Tissue: Mouse Pancreas lysatesAntibody Dilution: 1ug/ml)

Western Blot (WB) (Host: RabbitTarget Name: TUFMSample Tissue: Mouse Pancreas lysatesAntibody Dilution: 1ug/ml)
Related Product Information for anti-TUFM antibody
Description of Target: Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.

NCBI and Uniprot Product Information

NCBI GeneID
UniProt Accession #
Molecular Weight
49kDa
UniProt Protein Name
Elongation factor Tu, mitochondrial
UniProt Gene Name
Tufm
UniProt Entry Name
EFTU_MOUSE

Uniprot Description

EFTU: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Defects in TUFM are the cause of combined oxidative phosphorylation deficiency type 4 (COXPD4). COXPD4 is characterized by neonatal lactic acidosis, rapidly progressive encephalopathy, severely decreased mitochondrial protein synthesis, and combined deficiency of mtDNA-related mitochondrial respiratory chain complexes. Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.

Protein type: Mitochondrial; Translation elongation; Translation; RNA-binding

Cellular Component: membrane; mitochondrion; mitochondrial inner membrane; intracellular; myelin sheath

Molecular Function: GTPase activity; GTP binding; nucleotide binding; translation elongation factor activity

Biological Process: translational elongation; translation

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Product Notes

The TUFM tufm (Catalog #AAA3249870) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TUFM Antibody-middle region reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TUFM can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the TUFM tufm for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: DHGKTTLTAA ITKILAEGGG AKFKKYEEID NAPEERARGI TINAAHVEYS. It is sometimes possible for the material contained within the vial of "TUFM, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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