Mouse anti-Human Tubulin Polyglutamylase TTLL6 Polyclonal Antibody | anti-TTLL6 antibody

Tubulin Polyglutamylase TTLL6 (Tubulin--tyrosine Ligase-like Protein 6, TTLL6, TTL.6)

Cat. Num. AAA6006032

• Gene Names: TTLL6; TTL.6
• Reactivity: Human
• Applications: Western Blot, Immunofluorescence
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: Tubulin Polyglutamylase TTLL6; Polyclonal Antibody; Tubulin Polyglutamylase TTLL6 (Tubulin--tyrosine Ligase-like Protein 6; TTLL6; TTL.6); Anti -Tubulin Polyglutamylase TTLL6 (Tubulin--tyrosine Ligase-like Protein 6; anti-TTLL6 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human TTLL6.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MEGCLGVAVLRKLSTFSAYLEDHSYNVEQIWRDIEDVIIKTLISAHPIIRHNYHTCFPNHTLNSACFEILGFDILLDHKLKPWLLEVNHSPSFSTDSRLDKEVKDGLLYDTLVLINLESCDKKKVLEEERQRGQFLQQCCSREMRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLNSEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQPLTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVHLTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPHLISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRSHASAMRDPCMQDQEAYSHCLISGQKGCERS

• Applicable Applications for anti-TTLL6 antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: Suitable for use in Immunofluorescence and Western Blot.; Dilution: Immunofluorescence: 10ug/ml
• Immunogen: Full length human TTLL6, aa1-569 (NP_775894.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of TTLL6 expression in human colon using MBS6006032.)

Western Blot (WB)

(Western Blot analysis of TTLL6 expression in transfected 293T cell line by MBS6006032. Lane 1: TTLL6 transfected lysate (62.59kD). Lane 2: Non-transfected lysate.)

Immunofluorescence (IF)

(Immunofluorescence of MBS6006032 (10ug/ml) on HeLa cells.)

Product Categories/Family for anti-TTLL6 antibody

Antibodies; Abs to Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 195963418
• NCBI GeneID: 284076
• NCBI Accession #: NP_001124390.1
• NCBI GenBank Nucleotide #: NM_001130918.1
• UniProt Accession #: Q8N841; Q24KB1; Q24KB2; Q24KB6; Q24KF3; Q24KJ5; Q24KN7; Q24KS9; Q24KX1; Q24L13; B4DZJ5; C9J233
• Molecular Weight: 96,401 Da
• NCBI Official Full Name: tubulin polyglutamylase TTLL6 isoform 1
• NCBI Official Synonym Full Names: tubulin tyrosine ligase-like family, member 6
• NCBI Official Symbol: TTLL6
• NCBI Official Synonym Symbols: TTL.6
• NCBI Protein Information: tubulin polyglutamylase TTLL6; tubulin--tyrosine ligase-like protein 6
• UniProt Protein Name: Tubulin polyglutamylase TTLL6
• Protein Family: Tubulin polyglutamylase
• UniProt Gene Name: TTLL6
• UniProt Synonym Gene Names: TTL.6
• UniProt Entry Name: TTLL6_HUMAN

Uniprot Description

TTLL6: Polyglutamylase which preferentially modifies alpha- tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Belongs to the tubulin--tyrosine ligase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.-.-.-; Ligase

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: cytoplasm

Molecular Function: tubulin binding; protein binding; ligase activity

Biological Process: protein polyglutamylation; microtubule severing; microtubule bundle formation