Rabbit anti-Human Tubulin alpha-8 Chain Polyclonal Antibody | anti-TUBA8 antibody

Tubulin alpha-8 Chain (Alpha-tubulin 8, TUBA8, Tubulin alpha Chain-like 2, TUBAL2) APC

Cat. Num. AAA6397491

• Gene Names: TUBA8; TUBAL2
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Tubulin alpha-8 Chain; Polyclonal Antibody; Tubulin alpha-8 Chain (Alpha-tubulin 8; TUBA8; Tubulin alpha Chain-like 2; TUBAL2) APC; anti-TUBA8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human TUBA8.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-TUBA8 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human TUBA8, aa1-449 (NP_061816.1).
• Immunogen Sequence: MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFDAQASKINDDDSFTTFFSETGNGKHVPRAVMIDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLSVAEITSSCFEPNSQMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGTDSFEEENEGEEF
• Conjugate: APC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(TUBA8 rabbit polyclonal antibody. Western Blot analysis of TUBA8 expression in human kidney.)

Western Blot (WB)

(Western Blot analysis of TUBA8 expression in transfected 293T cell line by TUBA8 polyclonal antibody. Lane 1: TUBA8 transfected lysate (50.1kD). Lane 2: Non-transfected lysate.)

Product Categories/Family for anti-TUBA8 antibody

Antibodies; Tubulin

NCBI and Uniprot Product Information

• NCBI GI #: 9507215
• NCBI GeneID: 51807
• NCBI Accession #: NP_061816.1
• NCBI GenBank Nucleotide #: NM_018943.1
• UniProt Accession #: Q9NY65; Q2M3N4; B2RCX2; Q7Z3M3
• Molecular Weight: 50,094 Da
• NCBI Official Full Name: tubulin alpha-8 chain isoform 1
• NCBI Official Synonym Full Names: tubulin, alpha 8
• NCBI Official Symbol: TUBA8
• NCBI Official Synonym Symbols: TUBAL2
• NCBI Protein Information: tubulin alpha-8 chain; OTTHUMP00000196216; OTTHUMP00000196217; OTTHUMP00000196246; tubulin alpha chain-like 2
• UniProt Protein Name: Tubulin alpha-8 chain
• Protein Family: Tubulin
• UniProt Gene Name: TUBA8
• UniProt Synonym Gene Names: TUBAL2

Uniprot Description

TUBA8: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Defects in TUBA8 are the cause of polymicrogyria with optic nerve hypoplasia (PMGONH). It is a disease characterized by extensive polymicrogyria, optic nerve hypoplasia, severe developmental delay, hypotonia, seizures, a dysplastic or absent corpus callosum and colpocephaly. Polymicrogyria is a malformation of the cortex in which the brain surface is irregular and characterized by an excessive number of small gyri with abnormal lamination. Belongs to the tubulin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 22q11.21

Disease: Polymicrogyria With Optic Nerve Hypoplasia