Rabbit TUBA1A Polyclonal Antibody | anti-TUBA1A antibody

TUBA1A (Ab-40) Antibody

Cat. Num. AAA9507865

• Gene Names: TUBA1A; LIS3; TUBA3; B-ALPHA-1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
• Synonyms: TUBA1A; Polyclonal Antibody; TUBA1A (Ab-40) Antibody; anti-TUBA1A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: TUBA1A (Ab-40) Antibody detects endogenous levels of TUBA1A40 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 416

• Applicable Applications for anti-TUBA1A antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; ELISA: 1:10000
• Target Modification: Unmodified/Total
• Immunogen: The antiserum was produced against synthesized peptide derived from human TUBA1A around the non-acetylation site of Lys40.
• Immunogen Range: Jan-50
• Preparation and Storage: Stable at -20 degree C for at least 1 year.

Western Blot (WB)

(Western blot analysis of extracts from Jurkat cells, using TUBA1A (Ab-40) Antibody.)

NCBI and Uniprot Product Information

• NCBI GI #: 393715091
• NCBI GeneID: 7846
• NCBI Accession #: NP_001257328.1
• NCBI GenBank Nucleotide #: NM_001270399.1
• UniProt Accession #: Q71U36; P04687; P05209; A8K0B8; G3V1U9
• Molecular Weight: 50
• NCBI Official Full Name: tubulin alpha-1A chain isoform 1
• NCBI Official Synonym Full Names: tubulin alpha 1a
• NCBI Official Symbol: TUBA1A
• NCBI Official Synonym Symbols: LIS3; TUBA3; B-ALPHA-1
• NCBI Protein Information: tubulin alpha-1A chain
• UniProt Protein Name: Tubulin alpha-1A chain
• UniProt Gene Name: TUBA1A
• UniProt Synonym Gene Names: TUBA3

NCBI Description

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]

Uniprot Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.